Spatial compartmentalization of AMPA glutamate receptor subunits at the calyx of Held synapse

The Journal of Comparative Neurology
Diana HermidaP Grandes

Abstract

The mature calyx of Held ending on principal neurons of the medial nucleus of the trapezoid body (MNTB) has very specialized morphological and molecular features that make it possible to transmit auditory signals with high fidelity. In a previous work we described an increased localization of the ionotropic alpha-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid (AMPA) glutamate receptor (GluA) subunits at postsynaptic sites of the calyx of Held-principal cell body synapses from postnatal development to adult. The aim of the present study was to investigate whether the pattern of the synaptic distribution of GluA2/3/4c and -4 in adult MNTB principal cell bodies correlated with preferential subcellular domains (stalks and swellings) of the calyx. We used a postembedding immunocytochemical method combined with specific antibodies to GluA2/3/4c and GluA4 subunits. We found that the density of GluA2/3/4c in calyceal swellings (19 +/- 1.54 particles/microm) was higher than in stalks (10.93 +/- 1.37 particles/microm); however, the differences for GluA4 were not statistically significant (swellings: 13.84 +/- 1.39 particles/microm; stalks: 10.42 +/- 1.24 particles/microm). Furthermore, GluA2/3/4c and GluA4 labeling co-localized to so...Continue Reading

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Citations

Nov 1, 2011·Annual Review of Physiology·J Gerard G Borst, John Soria van Hoeve
Jan 29, 2014·The Journal of Physiology·Giovanbattista GrandeLu-Yang Wang
Dec 28, 2010·Hearing Research·Charles C Lee, S Murray Sherman
Feb 11, 2014·Hearing Research·Wei-Ming Yu, Lisa V Goodrich
Oct 24, 2014·Frontiers in Neural Circuits·Johana TrojanovaRostislav Turecek

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