Spatial constraints within the chlamydial host cell inclusion predict interrupted development and persistence

BMC Microbiology
Alexander HoareDavid P Wilson

Abstract

The chlamydial developmental cycle involves the alternation between the metabolically inert elementary body (EB) and the replicating reticulate body (RB). The triggers that mediate the interchange between these particle types are unknown and yet this is crucial for understanding basic Chlamydia biology. We have proposed a hypothesis to explain key chlamydial developmental events whereby RBs are replicating strictly whilst in contact with the host cell membrane-derived inclusion via type three secretion (T3S) injectisomes. As the inclusion expands, the contact between each RB and the inclusion membrane decreases, eventually reaching a threshold, beyond which T3S is inactivated upon detachment and this is the signal for RB-to-EB differentiation. We explore this hypothesis through the development of a detailed mathematical model. The model uses knowledge and data of the biological system wherever available and simulates the chlamydial developmental cycle under the assumptions of the hypothesis in order to predict various outcomes and implications under a number of scenarios. We show that the concept of in vitro persistent infection is not only consistent with the hypothesis but in fact an implication of it. We show that increasing...Continue Reading

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Citations

Jun 23, 2009·Journal of Bacteriology·David P WilsonPatrik M Bavoil
Jan 26, 2010·BMC Microbiology·Chris B StoneJames B Mahony
May 9, 2014·Future Microbiology·Nadja KädingJan Rupp
Oct 5, 2013·Bulletin of Mathematical Biology·Dann G MalletKelly-Jean Sutton
Sep 25, 2012·Microbial Pathogenesis·Eveliina MarkkulaMirja Puolakkainen
Dec 12, 2012·Trends in Microbiology·Eileen RoulisPeter Timms
Oct 26, 2010·Nature Reviews. Microbiology·Jonathan Dworkin, Ishita M Shah
Sep 19, 2012·Molekuliarnaia genetika, mikrobiologiia i virusologiia·N A ZigangirovaE A Kost
Dec 4, 2020·Nature Communications·Ralph GötzMarkus Sauer
Jul 30, 2015·Journal of Cell Science·Maud DumouxRichard D Hayward

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