Spatial distribution and temporal progression of T2 relaxation time values in knee cartilage prior to the onset of cartilage lesions - data from the Osteoarthritis Initiative (OAI)

Osteoarthritis and Cartilage
Martin KretzschmarThomas M Link

Abstract

To investigate compositional changes of knee cartilage at the site of newly appearing cartilage lesions and the surrounding cartilage 1-4 years prior to lesion onset using quantitative T2-measurements. Fifty-seven cartilage plates with newly appearing cartilage lesions from 45 knees (cases) and 52 plates from 26 control knees from the Osteoarthritis Initiative (OAI) cohort (controls) were evaluated. Using MRI T2-mapping, composition of local (the site of future lesions) and surrounding cartilage (remainder of the cartilage plate) was assessed 1-4 years prior to lesion onset. Analogous cartilage ROIs in control plates without cartilage lesions were assessed over 1-4 years. Mixed models were used to compare T2-means and change rates between local and surrounding cartilage within cases and controls, and to compare change rates in local and surrounding cartilage between cases and controls, adjusting for covariates. Four years prior to lesion onset, we found that local cartilage ROIs had higher T2-values compared to the surrounding cartilage. No such differences were found in control plates. In cases mean local T2-values were persistantly elevated compared to the surrounding cartilage prior to lesion onset reaching significance 1 ye...Continue Reading

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Citations

Oct 24, 2019·Current Opinion in Rheumatology·Vladimir JurasRavinder R Regatte
Sep 26, 2020·Therapeutic Advances in Musculoskeletal Disease·Jorge A Roman-BlasGabriel Herrero-Beaumont
Dec 27, 2019·Osteoarthritis and Cartilage·R KijowskiA Guermazi
Sep 8, 2021·Radiology·Majid ChalianUNKNOWN SNA QIBA MSK Biomarker Committee Members

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