Spatial Distribution of Attentional Modulation at Columnar Resolution in Macaque Area V4

Frontiers in Neural Circuits
Hisashi TanigawaAnna W Roe


Attention to a location in a visual scene affects neuronal responses in visual cortical areas in a retinotopically specific manner. Optical imaging studies have revealed that cortical responses consist of two components of different sizes: the stimulus-nonspecific global signal and the stimulus-specific mapping signal (domain activity). It remains unclear whether either or both of these components are modulated by spatial attention. In this study, to determine the spatial distribution of attentional modulation at columnar resolution, we performed cerebral blood volume (CBV)-based optical imaging in area V4 of monkeys performing a color change detection task in which spatial attention was manipulated. We found that spatial attention enhanced global signals of the hemodynamic responses, but did not affect stimulus-selective domain activities. These results indicate the involvement of global signals in neural processing of spatial attention. We propose that global signals reflect the neural substrate of the normalization pool in normalization models of attention.


Aug 1, 1992·Visual Neuroscience·D J Heeger
Oct 1, 1985·Journal of Neurophysiology·D A McCormickD A Prince
Nov 1, 1994·Journal of Neurophysiology·J D VictorB Mao
Mar 1, 1996·Journal of Neurophysiology·C E ConnorD C Van Essen
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·D MalonekA Grinvald
Dec 24, 1998·Cerebral Cortex·M C PiñonA P Sousa
Jan 12, 1999·Neuron·R B TootellA M Dale
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·S P GandhiG M Boynton
Apr 16, 1999·Nature Neuroscience·J A Brefczynski, E A DeYoe
Mar 11, 2000·Journal of Neurophysiology·C J McAdams, J H Maunsell
Jul 15, 2000·Neuron·J H ReynoldsR Desimone
Jul 13, 2001·Nature·N K LogothetisA Oeltermann
Dec 14, 2001·Journal of Neuroscience Methods·Li Min ChenAnna Wang Roe
Apr 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masahito NemotoArthur W Toga
May 26, 2004·Neuron·Stephanie A McMains, David C Somers
Aug 6, 2005·Science·Jörn NiessingRalf A W Galuske
May 16, 2006·Trends in Neurosciences·John H R Maunsell, Stefan Treue
Jun 15, 2006·Journal of Neurophysiology·Tori Williford, John H R Maunsell
Nov 17, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mitsuhiro FukudaSeong-Gi Kim
May 2, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pascal FriesRobert Desimone
Feb 3, 2009·Neuron·John H Reynolds, David J Heeger
Feb 28, 2009·PloS One·Joonyeol Lee, John H R Maunsell
Oct 16, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yevgeniy B SirotinAniruddha Das
Nov 17, 2009·Nature Neuroscience·Marlene R Cohen, John H R Maunsell
Nov 16, 2010·Nature Neuroscience·Hisashi TanigawaAnna W Roe
May 10, 2011·Vision Research·Marisa Carrasco
Nov 1, 2011·NeuroImage·Yevgeniy B SirotinAniruddha Das
Nov 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marlene R Cohen, John H R Maunsell
Nov 24, 2011·Nature Reviews. Neuroscience·Matteo Carandini, David J Heeger
Jul 31, 2012·Nature Neuroscience·Mariana M B CardosoAniruddha Das
Oct 17, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bruss LimaAniruddha Das

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