Spatial distribution of diabetic capillary non-perfusion.

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
Khalil Ghasemi FalavarjaniEsrafil Shad

Abstract

To evaluate the distribution of capillary non-perfusion (CNP) in superficial and deep capillary plexuses (SCP and DCP) in eyes with diabetic retinopathy (DR). In this retrospective case series, macular optical coherence tomography angiography (OCTA) images were obtained from eyes with DR without diabetic macular edema (DME). The area of CNP in SCP and DCP was delineated using an automated approach after excluding the foveal avascular zone (FAZ) and major retinal vessels. The distribution and spatial correlation of the CNP in each layer were analyzed. Forty-three eyes of 27 patients with DR with a mean age of 59.10 ± 9.05 years were included. The mean CNP area in SCP was statistically significantly higher than DCP (0.722 ± 0.437 mm2 vs. 0.184 ± 0.145 mm2 , respectively, p < .001). There was a statistically significant association between mean BCVA (0.28 ± 0.21 logMAR) and CNP area in DCP (p = .01). After automated subtraction of CNP areas in DCP from SCP, 25.43 ± 15.05% of CNP areas in the DCP had co-localized CNP areas in SCP. The CNP percentage was statistically significantly different between the concentric rings on foveal center, both in SCP and in DCP (both p < .001) showing a decreasing trend from the outer ring toward the...Continue Reading

References

May 1, 1995·Experimental Eye Research·T S Kern, R L Engerman
May 14, 2016·American Journal of Ophthalmology·Fabio ScarinciAmani A Fawzi
Jul 22, 2016·The British Journal of Ophthalmology·Khalil Ghasemi FalavarjaniSrinivas R Sadda
Apr 15, 2015·International Journal of Retina and Vitreous·Talisa E de CarloJay S Duker
Mar 17, 2017·Journal of Ophthalmic & Vision Research·Handan AkilAlfredo A Sadun
Apr 4, 2017·Journal of Current Ophthalmology·Khalil Ghasemi Falavarjani, David Sarraf
Oct 4, 2017·Investigative Ophthalmology & Visual Science·Enrico BorrelliSriniVas R Sadda
Jun 22, 2018·International Journal of Molecular Sciences·Wei Wang, Amy C Y Lo
Aug 7, 2018·American Journal of Ophthalmology·Mathieu F BakhoumDavid Sarraf
Nov 28, 2018·Journal of Ophthalmic & Vision Research·Joobin KhadamyKhalil Ghasemi Falavarjani
May 12, 2020·Investigative Ophthalmology & Visual Science·Sonja G KarstEduardo V Navajas

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Citations

Dec 5, 2021·Scientific Reports·Reza MirshahiKhalil Ghasemi Falavarjani

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