Spatial distribution of "tissue-specific" antigens in the developing human heart and skeletal muscle. III. An immunohistochemical analysis of the distribution of the neural tissue antigen G1N2 in the embryonic heart; implications for the development of the atrioventricular conduction system

The Anatomical Record
A WesselsA F Moorman

Abstract

A monoclonal antibody raised against an extract from the Ganglion Nodosum of the chick and designated G1N2 proves to bind specifically to a subpopulation of cardiomyocytes in the embryonic human heart. In the youngest stage examined (Carnegie stage 14, i.e., 4 1/2 weeks of development) these G1N2-expressing cells are localized in the myocardium that surrounds the foramen between the embryonic left and right ventricle. In the lesser curvature of the cardiac loop this "primary" ring occupies the lower part of the wall of the atrioventricular canal. During subsequent development, G1N2-expressing cells continue to identify the entrance to the right ventricle, but the shape of the ring changes as a result of the tissue remodelling that underlies cardiac septation. During the initial phases of this process the staining remains recognizable as a continuous band of cells in the myocardium that surrounds the developing right portion of the atrioventricular canal, subendocardially in the developing interventricular septum and around the junction of the embryonic left ventricle with the subaortic portion of the outflow tract. During the later stages of cardiac septation, the latter part of the ring discontinues to express G1N2, while upon...Continue Reading

References

Jun 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M WatanabeH Fallah-Najmabadi
Jul 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·P S Chan-ThomasP J Barton
Jan 15, 2002·The Anatomical Record·Arjan C HouwelingVincent M Christoffels
Nov 1, 1994·Trends in Cardiovascular Medicine·A F Moorman, W H Lamers
Jul 1, 1994·Trends in Cardiovascular Medicine·L GorzaM Vitadello
Aug 14, 2002·The Annals of Thoracic Surgery·Toyoki FukudaYukihiko Morikawa
Apr 6, 1999·Trends in Cardiovascular Medicine·Robert G GourdieTakashi Mikawa
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Terrence X O'brienK R Chien
Mar 4, 2011·Cardiovascular Research·David Sedmera
Jun 29, 2012·Cardiovascular Research·Barbora SankovaDavid Sedmera
Aug 1, 1997·Pacing and Clinical Electrophysiology : PACE·A F MoormanW H Lamers
Sep 9, 2005·Pediatric Research·Nico A BlomA C Gittenberger-de Groot
Jun 14, 2014·Journal of Developmental Biology·Marie M LockhartA Wessels
May 4, 2011·Cellular and Molecular Life Sciences : CMLS·C J J BoogerdP Barnett
May 29, 2000·Journal of Cardiovascular Electrophysiology·L M BevilacquaJ K Triedman
Apr 1, 1996·Journal of Cardiovascular Electrophysiology·Robert G Gourdie
Jun 6, 2012·Differentiation; Research in Biological Diversity·Monique R M JongbloedNico A Blom
Feb 10, 2007·Seminars in Cell & Developmental Biology·Takashi Mikawa, Romulo Hurtado
Sep 17, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Florence RothenbergMichiko Watanabe
Sep 26, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Brian S SnarrA Wessels
Mar 26, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Lucile MiquerolRobert G Kelly
Apr 19, 2011·Journal of Anatomy·Masahito YamamotoYoshinobu Ide
Jun 2, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Wim T J AanhaanenVincent M Christoffels
Nov 14, 2014·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Horia Muresian
Aug 1, 1991·International Journal of Cardiology·R H Anderson
Apr 28, 2005·The Annals of Thoracic Surgery·Mazyar KananiR H Anderson
Dec 15, 2010·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Tomokazu Kawashima, Hiroshi Sasaki
Sep 15, 2016·Journal of Cardiovascular Electrophysiology·Tamas Szili TorokSing-Chien Yap
Oct 27, 2006·Developmental Biology·Matthias StadtfeldThomas Graf
Dec 22, 2004·Pediatric Research·A C Gittenberger-de GrootRobert E Poelmann
Jun 30, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Semir SomiMaurice J B Van Den Hoff
Jan 21, 2016·Development·Jan Hendrik van Weerd, Vincent M Christoffels
May 19, 2018·Pediatric Cardiology·Rajiv A MohanVincent M Christoffels
Sep 16, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Brett S HarrisRobert G Gourdie
Jun 17, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Semir SomiMaurice J B Van Den Hoff
Sep 24, 2004·The Anatomical Record. Part B, the New Anatomist·Robert H AndersonA F Moorman
Aug 24, 2018·Journal of Cardiovascular Development and Disease·R H AndersonBjarke Jensen

Citations

Nov 1, 1978·The Anatomical Record·R C TruexD R Marino
Jan 1, 1990·Anatomy and Embryology·H D HasselbainkW H Lamers
Aug 9, 1988·Brain Research·L GorzaM Vitadello
May 1, 1986·The Anatomical Record·E SzabóC E Challice
Jan 1, 1985·International Journal of Cardiology·H Kurosawa, A E Becker
Dec 1, 1972·British Heart Journal·R H Anderson, I M Taylor
Jan 1, 1965·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·A Yamauchi
Jun 1, 1984·Cell Differentiation·A F MoormanR Charles
Jan 1, 1982·Developmental Biology·S Viragh, C E Challice
Jan 1, 1981·Virchows Archiv. A, Pathological Anatomy and Histology·A C Wenink

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Vertebrates
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