Spatial distributions of on- and off-responses determined with the multifocal ERG.

Documenta Ophthalmologica. Advances in Ophthalmology
Anderson R RodriguesJ Kremers

Abstract

We studied the contribution of retinal on and off-mechanisms in the multifocal electroretinogram (mfERG) by measuring responses to saw tooth stimuli. Six healthy subjects participated in this study. Rapid-on and rapid-off sawtooth stimuli with a period of 427 ms were presented in a multifocal pattern composed of 19 hexagons. The stimuli were interleaved with a blank field of the mean luminance and chromaticity. On- and off-responses were added to extract response asymmetries. The amplitudes of on-, off-, and added-responses were determined for different eccentricities relative to a signal baseline that was defined as the average of the electrical level recorded in two different time windows in which no responses were present. Measurements were repeated with eight different stimulus stretch factors to account for changes in retinal cell density as a function of eccentricity. The amplitudes of all ERG components decreased with increasing eccentricity for all stretch factors. For stretch factors between 0 and 20, responses to the central and immediately adjacent hexagons were large in amplitude. For more peripheral hexagons, the responses were very small or absent. Three components were identified in the on-responses (N20(on), P46...Continue Reading

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Citations

Jul 31, 2014·Documenta Ophthalmologica. Advances in Ophthalmology·Eric VukmanicPaul DeMarco
Feb 4, 2011·Documenta Ophthalmologica. Advances in Ophthalmology·M RasterJ Kremers
Mar 30, 2012·Documenta Ophthalmologica. Advances in Ophthalmology·Gobinda PangeniJan Kremers
Apr 4, 2014·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Jan KremersNeil R A Parry
Feb 19, 2016·Journal of Neurophysiology·Nina RiddellDavid P Crewther
Mar 15, 2016·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Tina I TsaiJan Kremers
Oct 17, 2020·Documenta Ophthalmologica. Advances in Ophthalmology·Mathias G NittmannRadouil Tzekov

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