PMID: 9548551Apr 21, 1998Paper

Spatial distributions of retinoic acid receptor gene transcripts in the prenatal mouse inner ear

The Journal of Comparative Neurology
R RomandP Dollé

Abstract

The expression patterns of the three mouse retinoic acid (RA) receptor gene isotypes (RARalpha, RARbeta, and RARgamma) and retinoid X receptor gene isotypes (RXRalpha, RXRbeta, and RXRgamma) have been investigated by in situ hybridization analysis of their RNA transcripts in the inner ear of mouse fetuses at 18.5 days of gestation. Two RARs (RARalpha and RARgamma) and two RXRs (RXRalpha and RXRbeta) presented an almost ubiquitous transcript distribution with overlapping expression in several regions of the cochlea, such as Kölliker's organ, the organ of Corti, the spiral limbus, and nervous structures. The organ of Corti showed an enhanced in situ labeling with RARalpha and RXRbeta. By contrast, RARbeta and RXRgamma displayed more restricted expression patterns. RXRgamma in particular was strongly expressed in Kölliker's organ and in the spiral ganglion. This expression pattern suggests that RA may be involved in the differentiation of several cochlear cell types. Moreover, the colocalization of several RAR and RXR gene transcripts suggests possible heterodimerization between these receptors in several regions of the cochlea.

Citations

Nov 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Karen NiederreitherPascal Dolle
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·J S Stone, E W Rubel
Mar 18, 2003·Molecular and Cellular Biology·Deborah L ThompsonRonald J Koenig
Mar 5, 2009·The Journal of Comparative Neurology·Luis Oscar Sánchez-GuardadoMatías Hidalgo-Sánchez
Aug 24, 1999·Developmental Biology·Y Raz, M W Kelley
Feb 1, 2018·Birth Defects Research·Nancy BakerGeorge Daston
May 28, 2009·Nuclear Receptor Signaling·Pascal Dollé
May 12, 2006·Journal of Neurobiology·Raymond RomandEri Hashino
May 12, 2006·Journal of Neurobiology·Margaret Clagett-DameParag D Muley
Sep 19, 2019·International Journal of Environmental Research and Public Health·Sang Hyun KwakJinsei Jung
Dec 5, 2002·Mechanisms of Development·Raymond RomandNorbert B Ghyselinck

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