Spatial gradient sensing and chemotaxis via excitability in Dictyostelium discoideum.

Physical Review. E
Daniel P ShamsDavid J Schwab

Abstract

The social amoeba Dictyostelium discoideum performs chemotaxis under starvation conditions, aggregating towards clusters of cells following waves of the signaling molecule cAMP. Cells sense extracellular cAMP and produce internal caches of cAMP to be released, relaying the signal. These events lead to traveling waves of cAMP washing over the population of cells. While much research has been performed to understand the functioning of the chemotaxis network in D. discoideum, limited work has been done to link the operation of the signal relay network with the chemotaxis network to provide a holistic view of the system. We take inspiration from D. discoideum and propose a model that directly links the relaying of a chemical message to the directional sensing of that signal. Utilizing an excitable dynamical systems model that has been previously validated experimentally, we show that it is possible to have both signal amplification and perfect adaptation in a single module. We show that noise plays a vital role in chemotaxing to static gradients, where stochastic tunneling of transient bursts biases the system towards accurate gradient sensing. Moreover, this model also automatically matches its internal time scale of adaptation to...Continue Reading

References

Nov 1, 1977·Biophysical Journal·H C Berg, E M Purcell
Sep 1, 1984·The Journal of Cell Biology·B Varnum, D R Soll
Apr 17, 2001·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·H LevineI Cohen
Oct 4, 2003·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Hervé Henry, Herbert Levine
Nov 5, 2003·Molecular Biology of the Cell·Marten PostmaPeter J M Van Haastert
Sep 7, 2004·Biophysical Journal·Günther GerischKurt Anderson
Sep 24, 2004·Current Opinion in Genetics & Development·Alan R Kimmel, Richard A Firtel
Oct 26, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·R E Lee DeVilleCyrill B Muratov
Dec 13, 2007·Journal of Cell Science·Douwe M Veltman, Peter J M van Haastert
Jan 22, 2008·Current Opinion in Cell Biology·Pablo A Iglesias, Peter N Devreotes
Jan 25, 2008·Development·Christophe Anjard, William F Loomis
Jul 29, 2008·Ageing Research Reviews·Vanessa C McMainsAlan R Kimmel
Apr 9, 2009·Journal of Computational Neuroscience·Brian Nils LundstromAdrienne L Fairhall
Nov 13, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Thomas Butler, Nigel Goldenfeld
Apr 24, 2010·Science·Thomas GregorSatoshi Sawai
May 21, 2010·Physical Review Letters·Inbal HechtHerbert Levine
Jul 28, 2013·Journal of Cell Science·Arjan KortholtPeter J M Van Haastert
May 23, 2014·Cellular and Molecular Life Sciences : CMLS·Yulia ArtemenkoPeter N Devreotes
Sep 25, 2014·Proceedings of the National Academy of Sciences of the United States of America·Monica SkogeWouter-Jan Rappel
Oct 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Chuan-Hsiang Huang, Pablo A Iglesias
Nov 7, 2014·Nature Communications·Akihiko NakajimaSatoshi Sawai
May 3, 2016·Cell Systems·James E Ferrell
Aug 11, 2017·Annual Review of Cell and Developmental Biology·Peter N DevreotesYuchuan Miao

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