Spatial homogeneity and task-synchrony of the trial-related hemodynamic signal.

NeuroImage
Yevgeniy B SirotinAniruddha Das

Abstract

There is growing evidence that functional brain images in alert task-engaged subjects contain task-related but stimulus-independent signals in addition to stimulus-evoked responses. It is important to separate these different components when analyzing the neuroimaging signal. Using intrinsic-signal optical imaging combined with electrophysiology we had earlier reported a particular 'trial-related signal' in the primary visual cortex (V1) of alert monkeys performing periodic fixation tasks. This signal periodically modulated V1 tissue blood volume, in time with anticipated trial onsets. Unlike visually evoked blood volume changes, however, this signal was present even in total darkness. Further, it could not be predicted by concurrently recorded spiking or local field potentials. Here we use our earlier recording techniques to analyze the spatial distribution of this trial-related signal over our imaged area (10mm square, subdivided into a 16×16 grid, i.e. at 625 μm resolution). We show that the signal is spatially coherent and essentially homogeneous over the imaged region and fails to be predicted by concurrent electrode recordings even at the resolution of a single grid square at the electrode tip. As a corollary we show that...Continue Reading

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Oct 16, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yevgeniy B SirotinAniruddha Das

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Citations

Jul 31, 2012·Nature Neuroscience·Mariana M B CardosoAniruddha Das
Feb 9, 2013·Brain Structure & Function·Barbara Heider, Ralph M Siegel
Apr 20, 2019·PLoS Biology·Mariana M B CardosoAniruddha Das
Apr 10, 2019·Proceedings of the National Academy of Sciences of the United States of America·Alex L WhiteJason D Yeatman
Dec 27, 2016·Frontiers in Neural Circuits·Hisashi TanigawaAnna W Roe
Nov 17, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Aniruddha DasPatrick J Drew

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