Spatial interaction between tissue pressure and skeletal muscle perfusion during contraction

Journal of Biomechanics
C C van DonkelaarM R Drost

Abstract

The vascular waterfall theory attributes decreased muscle perfusion during contraction to increased intramuscular pressure (P(IM)) and concomitant increase in venous resistance. Although P(IM) is distributed during contractions, this theory does not account for heterogeneity. This study hypothesises that pressure heterogeneity could affect the interaction between P(IM) rise and perfusion. Regional tissue perfusion during submaximum (100kPa) tetanic contraction is studied, using a finite element model of perfused contracting skeletal muscle. Capillary flow in muscles with one proximal artery and vein (SIM(1)) and with an additional distal artery and vein (SIM(2)) is compared. Blood flow and pressures at rest and P(IM) during contraction ( approximately 25kPa maximally) are similar between simulations, but capillary flow and venous pressure differ. In SIM(2), venous pressure and capillary flow correspond to P(IM) distribution, whereas capillary flow in SIM(1) is less than 10% of flow in SIM(2), in the muscle half without draining vein. This difference is caused by a high central P(IM), followed by central venous pressure rise, in agreement with the waterfall theory. The high central pressure (SIM(1)), obstructs outflow from the d...Continue Reading

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Citations

Sep 28, 2007·Annals of Biomedical Engineering·Eran Linder-Ganz, Amit Gefen
Nov 10, 2009·Neurocritical Care·Yanbing YuQi Pang
Aug 4, 2011·Computer Methods in Biomechanics and Biomedical Engineering·L DubuisP Badel
Dec 2, 2004·Journal of Theoretical Biology·D BauerA Ehrlacher
May 20, 2015·Medical & Biological Engineering & Computing·Piero G PavanArturo N Natali
Dec 9, 2003·Journal of Applied Physiology·Gisela SjøgaardKaren Søgaard

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