PMID: 9166750Jun 1, 1997Paper

Spatial learning activates neural cell adhesion molecule polysialylation in a corticohippocampal pathway within the medial temporal lobe

Journal of Neurochemistry
A W O'ConnellC M Regan

Abstract

Transient and time-dependent modulations of neural cell adhesion molecule (NCAM) polysialylation in the dentate gyrus of the rodent hippocampus are a feature of spatial and nonspatial forms of learning. In the hippocampal formation, polysialic acid immunoreactivity was localized to granule-like cells and their mossy fibre axons. We now demonstrate the latter to extend to the CA3 region where apparent recurrent and Schaffer collaterals were labelled. The axons of the CA1 pyramidal cell layer were immunopositive, as was the subiculum that they innervate. Layers I and III of the entorhinal cortex stained intensely for polysialic acid; however, these were not visible in the more lateral aspect of this region and were replaced by a single band of immunopositive neurons that extended to include the perirhinal and piriform cortices. After Morris water maze training, the number of polysialylated neurons within the entorhinal cortex exhibited a two- to threefold increase at the 10-12-h posttraining time with respect to that observed immediately after training. This increase was task specific, as no change was observed in freely swimming animals or those required to locate a visible platform. These results suggest the presence of a corti...Continue Reading

Citations

Jan 21, 2000·Hippocampus·V Ramírez-AmayaF Bermúdez-Rattoni
Apr 18, 2009·Cell Adhesion & Migration·Luca Bonfanti, Dionysia T Theodosis
Feb 2, 2010·Journal of Materials Science. Materials in Medicine·Stephanie SteinhausPeter Behrens
Mar 15, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L C RønnE Bock
Jul 19, 2003·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Hans Welzl, Oliver Stork
Dec 7, 2007·Nature Reviews. Neuroscience·Urs Rutishauser
Mar 24, 2006·The European Journal of Neuroscience·César VeneroCarmen Sandi
Jul 3, 2020·Cellular and Molecular Life Sciences : CMLS·Vladimir SytnykMelitta Schachner
Jul 7, 2009·Annual Review of Nutrition·Bing Wang
Aug 7, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrew G FoleyCiaran M Regan
Nov 18, 1998·Current Opinion in Structural Biology·M MühlenhoffR Gerardy-Schahn
Oct 18, 2000·European Journal of Pharmacology·M P Vawter
Jul 27, 2001·European Journal of Pharmacology·A W O'ConnellC M Regan
Oct 13, 2006·Progress in Neurobiology·Luca Bonfanti

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