Spatial learning deficits induced by chronic prenatal ethanol exposure can be overcome by non-spatial pre-training

Neurotoxicology and Teratology
Umar IqbalJ N Reynolds

Abstract

This study tested the hypothesis that behavioural intervention, in the form of non-spatial pre-training, mitigates the deficits in spatial learning tasks induced in guinea pig offspring by chronic prenatal ethanol exposure (CPEE). Timed, pregnant guinea pigs were treated with ethanol (4 g/kg maternal body weight/day), isocaloric-sucrose/pair-feeding, or water throughout gestation. Offspring received non-spatial pre-training, in which animals were exposed to the procedural requirements of the water maze in the absence of distal spatial cues, and then were tested in both stationary-platform and moving-platform tasks with spatial cues. Saliva cortisol was quantified in non-trained and pre-trained animals before and after exposure to the water maze. CPEE offspring exhibited performance deficits in the stationary-platform task, and non-spatial pre-training improved performance of CPEE offspring to control levels. In contrast, non-spatial pre-training had no effect on the impaired performance of CPEE offspring in the moving-platform task. Non-trained CPEE offspring had elevated saliva cortisol concentration after water-maze exposure compared to control offspring. Moreover, pre-trained control animals exhibited a sensitization of the ...Continue Reading

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Citations

Oct 28, 2011·Nutrition Reviews·Francesca FoltranMarcello Giovannini
Nov 4, 2015·Brain Sciences·Balapal S Basavarajappa
May 18, 2010·Brain Research Reviews·Joana Gil-MohapelBrian R Christie
Sep 13, 2008·Behavioural Brain Research·Amita KapoorStephen G Matthews

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