Spatial memory and the monkey hippocampus: not all space is created equal

Hippocampus
Pamela Banta Lavenex, Pierre Lavenex

Abstract

Studies of the role of the monkey hippocampus in spatial learning and memory, however few, have reliably produced inconsistent results. Whereas the role of the hippocampus in spatial learning and memory has been clearly established in rodents, studies in nonhuman primates have made a variety of claims that range from the involvement of the hippocampus in spatial memory only at relatively longer memory delays, to no role for the hippocampus in spatial memory at all. In contrast, we have shown that selective damage restricted to the hippocampus (CA regions) prevents the learning or use of allocentric, spatial relational representations of the environment in freely behaving adult monkeys tested in an open-field arena. In this commentary, we discuss a unifying framework that explains these apparently discrepant results regarding the role of the monkey hippocampus in spatial learning and memory. We describe clear and strict criteria to interpret the findings from previous studies and guide future investigations of spatial memory in monkeys. Specifically, we affirm that, as in the rodent, the primate hippocampus is critical for spatial relational learning and memory, and in a time-independent manner. We describe how claims to the con...Continue Reading

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Citations

Jul 25, 2013·Journal of the International Neuropsychological Society : JINS·Shala N BlueJocelyne Bachevalier
Mar 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Patrick A ForcelliLudise Malkova
Jun 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Timothy A Allen, Norbert J Fortin
Oct 6, 2012·Cognitive Psychology·Farfalla RibordyPierre Lavenex
Mar 5, 2011·Current Opinion in Neurobiology·Gabrielle Girardeau, Michaël Zugaro
Mar 24, 2010·Behavioural Brain Research·Edmund T Rolls
Feb 24, 2011·The Journal of Comparative Neurology·Adeline JabèsPierre Lavenex
Jan 16, 2010·The European Journal of Neuroscience·Adeline JabèsPierre Lavenex
Jan 21, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Edmund T Rolls
Jan 18, 2011·Behavioural Brain Research·Pamela Banta LavenexPierre Lavenex
Jan 26, 2010·Neuropsychologia·Elisabeth A Murray, Steven P Wise
Mar 3, 2015·Cognitive Psychology·Pamela Banta LavenexPierre Lavenex
Mar 13, 2015·Frontiers in Psychology·Pamela Banta LavenexStefano Vicari
Aug 21, 2014·Frontiers in Human Neuroscience·Thomas Wolbers, Jan M Wiener
Oct 14, 2014·Frontiers in Human Neuroscience·Pamela A Banta LavenexPierre Lavenex
Dec 3, 2014·Neuroscience and Biobehavioral Reviews·Raymond P Kesner, Edmund T Rolls
Dec 9, 2017·Cell and Tissue Research·Edmund T Rolls
Aug 3, 2018·Hippocampus·Benjamin M Basile, Robert R Hampton
Nov 13, 2018·Frontiers in Psychology·Mathilde BostelmannPierre Lavenex
Dec 29, 2020·Frontiers in Psychology·Mathilde BostelmannPamela Banta Lavenex
Nov 27, 2020·Neurobiology of Learning and Memory·Anastasia Morandi-Raikova, Uwe Mayer
Jun 15, 2021·Frontiers in Psychiatry·Pamela Banta Lavenex, Pierre Lavenex
Nov 23, 2021·Frontiers in Aging Neuroscience·Adeline JabèsPierre Lavenex

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