Spatial Metrics of Tumour Vascular Organisation Predict Radiation Efficacy in a Computational Model

PLoS Computational Biology
Jacob G ScottPhilip K Maini

Abstract

Intratumoural heterogeneity is known to contribute to poor therapeutic response. Variations in oxygen tension in particular have been correlated with changes in radiation response in vitro and at the clinical scale with overall survival. Heterogeneity at the microscopic scale in tumour blood vessel architecture has been described, and is one source of the underlying variations in oxygen tension. We seek to determine whether histologic scale measures of the erratic distribution of blood vessels within a tumour can be used to predict differing radiation response. Using a two-dimensional hybrid cellular automaton model of tumour growth, we evaluate the effect of vessel distribution on cell survival outcomes of simulated radiation therapy. Using the standard equations for the oxygen enhancement ratio for cell survival probability under differing oxygen tensions, we calculate average radiation effect over a range of different vessel densities and organisations. We go on to quantify the vessel distribution heterogeneity and measure spatial organization using Ripley's L function, a measure designed to detect deviations from complete spatial randomness. We find that under differing regimes of vessel density the correlation coefficient ...Continue Reading

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Citations

Sep 14, 2016·IEEE Transactions on Bio-medical Engineering·James A GroganHelen M Byrne
May 8, 2018·Bulletin of Mathematical Biology·Nara YoonJacob G Scott
Jul 18, 2019·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Ibrahim M Chamseddine, Katarzyna A Rejniak
Jan 26, 2018·Journal of the Royal Society, Interface·Aleksandra KarolakKatarzyna A Rejniak
Oct 31, 2019·Systematic Biology·Jacob G ScottAlexander G Fletcher
Jul 17, 2020·Frontiers in Bioengineering and Biotechnology·Thomas E GorochowskiDaniel Ward
Aug 28, 2020·British Journal of Cancer·David Robert GrimesDavid Basanta
Dec 11, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jacob G ScottJavier F Torres-Roca
Jan 24, 2021·International Journal of Radiation Oncology, Biology, Physics·Jessica A ScarboroughJacob G Scott
Oct 29, 2020·Proceedings of the National Academy of Sciences of the United States of America·Miguel O BernabeuHelen M Byrne

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Methods Mentioned

BETA
biopsies
biopsy

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