Spatial pattern analysis of functional brain images using partial least squares

NeuroImage
A R McIntoshCheryl L Grady

Abstract

This paper introduces a new tool for functional neuroimage analysis: partial least squares (PLS). It is unique as a multivariate method in its choice of emphasis for analysis, that being the covariance between brain images and exogenous blocks representing either the experiment design or some behavioral measure. What emerges are spatial patterns of brain activity that represent the optimal association between the images and either of the blocks. This process differs substantially from other multivariate methods in that rather than attempting to predict the individual values of the image pixels, PLS attempts to explain the relation between image pixels and task or behavior. Data from a face encoding and recognition PET rCBF study are used to illustrate two types of PLS analysis: an activation analysis of task with images and a brain-behavior analysis. The commonalities across the two analyses are suggestive of a general face memory network differentially engaged during encoding and recognition. PLS thus serves as an important extension by extracting new information from imaging data that is not accessible through other currently used univariate and multivariate image analysis tools.

Citations

Jul 27, 2010·Cell Biochemistry and Biophysics·Christian HabeckUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jun 3, 1999·Psychophysiology·B F O'DonnellM E Shenton
Oct 8, 2008·Development and Psychopathology·Sally E Shaywitz, Bennett A Shaywitz
Oct 29, 2008·Journal of the International Neuropsychological Society : JINS·William J Tippett, Sandra E Black
Aug 8, 2013·Journal of the International Neuropsychological Society : JINS·Laura HopfSandra N Moses
Jun 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Fernando KasanetzM Gustavo Murer
Aug 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Victoria C MartinDonna Rose Addis
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·L NybergE Tulving
Feb 1, 2000·Cognitive Neuropsychology·C L GradyS I Rapoport
Apr 20, 2013·Brain Connectivity·Emily L Parks, David J Madden
Mar 8, 2005·Cerebral Cortex·Yaakov SternRonald van Heertum
Sep 14, 2006·Cerebral Cortex·Jeremy B CaplanEve De Rosa
Jul 10, 2012·Cerebral Cortex·Aristotle N VoineskosJames L Kennedy
Nov 6, 2008·Social Cognitive and Affective Neuroscience·Michelle L KeightleyCheryl L Grady
Mar 3, 2010·Social Cognitive and Affective Neuroscience·Michelle L KeightleyCheryl L Grady
Apr 3, 2008·Neuroreport·Emanuela TuraSteven G Potkin
Aug 31, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K M PeterssonA P Holmes
Mar 7, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K FristonC Büchel
Aug 10, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Barry HorwitzTheresa W Long
Mar 8, 2008·Learning & Memory·Deborah TalmiMorris Moscovitch
Feb 24, 2001·Alcoholism, Clinical and Experimental Research·M Vogel-SprottA Justus
Feb 4, 1999·Annals of the New York Academy of Sciences·A R McIntosh
Dec 17, 2004·Journal of Cognitive Neuroscience·Brian LevineAnthony R McIntosh
Apr 9, 2005·Journal of Cognitive Neuroscience·M N Rajah, A R McIntosh
Aug 17, 2005·Journal of Cognitive Neuroscience·Agatha Lenartowicz, Anthony R McIntosh
Jul 15, 2006·Journal of Cognitive Neuroscience·K SchiltzE Düzel
Aug 24, 2007·Journal of Cognitive Neuroscience·Hana Burianova, Cheryl L Grady
Mar 29, 2008·Journal of Cognitive Neuroscience·Margaret C McKinnonBrian Levine
Nov 20, 2008·Journal of Cognitive Neuroscience·Jeremy B CaplanAnthony R McIntosh
Aug 16, 2008·Journal of Cognitive Neuroscience·Zara M BergströmAlan Richardson-Klavehn
Mar 31, 2010·Journal of Cognitive Neuroscience·Antonino VallesiDonald T Stuss
Mar 31, 2010·Journal of Cognitive Neuroscience·Darlene FlodenDonald T Stuss

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