Spatial Patterns of Plasmodium falciparum Clinical Incidence, Asymptomatic Parasite Carriage and Anopheles Density in Two Villages in Mali

The American Journal of Tropical Medicine and Hygiene
Mahamadou S SissokoOgobara K Doumbo

Abstract

Heterogeneity in malaria exposure is most readily recognized in areas with low-transmission patterns. By comparison, little research has been done on spatial patterns in malaria exposure in high-endemic settings. We determined the spatial clustering of clinical malaria incidence, asymptomatic parasite carriage, and Anopheles density in two villages in Mali exposed to low- and mesoendemic-malaria transmission. In the two study areas that were < 1 km(2) in size, we observed evidence for spatial clustering of Anopheles densities or malaria parasite carriage during the dry season. Anopheles density and malaria prevalence appeared associated in some of our detected hotspots. However, many households with high parasite prevalence or high Anopheles densities were located outside the identified hotspots. Our findings indicate that within small villages exposed to low- or mesoendemic-malaria transmission, spatial patterns in mosquito densities and parasite carriage are best detected in the dry season. Considering the high prevalence of parasite carriage outside detected hotspots, the suitability of the area for targeting control efforts to households or areas of more intense malaria transmission may be limited.

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Citations

Apr 4, 2018·Malaria Journal·Boukary OuedraogoJean Gaudart
Jul 1, 2017·BMC Medicine·Polycarp MogeniUNKNOWN Hotspot Group Authors
Jul 17, 2019·BMC Medical Research Methodology·Abdoulaye GuindoJean Gaudart
Apr 20, 2017·Malaria Journal·Kelly M SearleUNKNOWN Southern Africa International Centers of Excellence for Malaria Research
Oct 24, 2017·Malaria Journal·Mahamadou Soumana SissokoJean Gaudart
Apr 22, 2017·Malaria Journal·Melanie Bannister-TyrrellKoen Peeters Grietens
Jun 20, 2020·BMC Infectious Diseases·Sokhna DiengJean Gaudart
Jul 15, 2021·Scientific Reports·Noah T VentimigliaMark A Travassos

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