Spatial readout of visual looming in the central brain of Drosophila.

ELife
Mai M MorimotoMichael B Reiser

Abstract

Visual systems can exploit spatial correlations in the visual scene by using retinotopy, the organizing principle by which neighboring cells encode neighboring spatial locations. However, retinotopy is often lost, such as when visual pathways are integrated with other sensory modalities. How is spatial information processed outside of strictly visual brain areas? Here, we focused on visual looming responsive LC6 cells in Drosophila, a population whose dendrites collectively cover the visual field, but whose axons form a single glomerulus-a structure without obvious retinotopic organization-in the central brain. We identified multiple cell types downstream of LC6 in the glomerulus and found that they more strongly respond to looming in different portions of the visual field, unexpectedly preserving spatial information. Through EM reconstruction of all LC6 synaptic inputs to the glomerulus, we found that LC6 and downstream cell types form circuits within the glomerulus that enable spatial readout of visual features and contralateral suppression-mechanisms that transform visual information for behavioral control.

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Citations

Oct 13, 2021·Current Biology : CB·Chenghao ChenJohn C Tuthill

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Methods Mentioned

BETA
light microscopy
transmission electron microscopy
Fluorescence

Software Mentioned

Thunder
Fiji
R Core Team
VVD Viewer Viewer
CATMAID
MATLAB
VVD viewer
R

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