Spatial structure of the dimeric transmembrane domain of the growth factor receptor ErbB2 presumably corresponding to the receptor active state

The Journal of Biological Chemistry
Eduard V BocharovAlexander S Arseniev

Abstract

Proper lateral dimerization of the transmembrane domains of receptor tyrosine kinases is required for biochemical signal transduction across the plasma membrane. The spatial structure of the dimeric transmembrane domain of the growth factor receptor ErbB2 embedded into lipid bicelles was obtained by solution NMR, followed by molecular dynamics relaxation in an explicit lipid bilayer. ErbB2 transmembrane segments associate in a right-handed alpha-helical bundle through the N-terminal tandem GG4-like motif Thr652-X3-Ser656-X3-Gly660, providing an explanation for the pathogenic power of some oncogenic mutations.

References

Jan 1, 1984·Progress in Biophysics and Molecular Biology·E N Baker, R E Hubbard
Feb 1, 1996·Journal of Molecular Graphics·R KoradiK Wüthrich
Dec 1, 1996·Journal of Biomolecular NMR·R A LaskowskiJ M Thornton
Sep 2, 1999·Current Biology : CB·G Jiang, T Hunter
Mar 4, 2000·Journal of the National Cancer Institute·D XieW Zheng
Nov 1, 2000·Cell·J Schlessinger
Dec 14, 2001·The Journal of Biological Chemistry·Jeannine M MendrolaMark A Lemmon
Jul 24, 2002·Biochemistry·Steven O SmithSaburo Aimoto
Dec 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sarel J FleishmanNir Ben-Tal
Jan 23, 2003·Biopolymers·Anthony W PartridgeCharles M Deber
Sep 2, 2003·Current Opinion in Structural Biology·A Rachael Curran, Donald M Engelman
Feb 13, 2004·The Journal of Biological Chemistry·Eduard V BocharovAlexander S Arseniev
May 18, 2004·Molecular Biology of the Cell·Amar BennasrounePierre Hubert
May 11, 2006·Chemical Reviews·Kevin R Mackenzie
Jan 24, 2007·Bioinformatics·Angela EnoshDan Halperin
Jan 27, 2007·Biochemistry·Jean-Pierre DuneauJames N Sturgis
Mar 31, 2007·Science·Hang YinWilliam F DeGrado

❮ Previous
Next ❯

Citations

Jul 16, 2009·The Journal of Membrane Biology·Ricky SoongKalina Hristova
Jul 13, 2012·Nature Reviews. Cancer·Yosef Yarden, Gur Pines
May 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Alexandre BrutusGiulia De Lorenzo
Jan 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Chihiro MatsushitaTakeshi Sato
Aug 30, 2008·The Journal of Biological Chemistry·Eduard V BocharovAlexander S Arseniev
Mar 8, 2012·Molekuliarnaia biologiia·M V GoncharukM P Kirpichnikov
Nov 26, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Robert Roskoski
Dec 10, 2013·Journal of the National Cancer Institute·Hiromasa YamamotoShinichi Toyooka
Feb 27, 2014·Proceedings of the National Academy of Sciences of the United States of America·Benjamin K MuellerAlessandro Senes
Aug 19, 2014·Journal of Computer-aided Molecular Design·Juan Felipe Franco-GonzalezJavier Martinez-Salazar
Feb 4, 2016·Trends in Pharmacological Sciences·Carole DeytsAngèle T Parent
May 1, 2013·Current Opinion in Structural Biology·Kirill Oxenoid, James J Chou
Aug 27, 2011·Current Opinion in Structural Biology·Nicholas F EndresJohn Kuriyan
Jun 21, 2011·Current Opinion in Chemical Biology·CongBao Kang, Qingxin Li
Jul 20, 2011·Journal of Molecular Biology·Lijuan HeWilliam C Wimley
Jun 24, 2010·Current Opinion in Structural Biology·Thomas RaschleGerhard Wagner
May 18, 2010·Journal of Molecular Biology·Konstantin S MineevAlexander S Arseniev
Aug 18, 2009·Chemistry and Physics of Lipids·Natalie Bordag, Sandro Keller
Jun 17, 2009·Protein Science : a Publication of the Protein Society·Dieter Langosch, Isaiah T Arkin
Aug 16, 2011·Biochimica Et Biophysica Acta·Derek P NgCharles M Deber
Aug 16, 2011·Biochimica Et Biophysica Acta·Lijuan He, Kalina Hristova
Oct 6, 2009·Biochimica Et Biophysica Acta·Lichi ShiVladimir Ladizhansky
Aug 11, 2011·Biochimica Et Biophysica Acta·Florian CymerDirk Schneider
Sep 14, 2011·Biochimica Et Biophysica Acta·Edwin LiKalina Hristova
Jul 5, 2013·Biophysical Journal·Sarvenaz Sarabipour, Kalina Hristova
Apr 8, 2016·ELife·Sarvenaz SarabipourKalina Hristova
Aug 6, 2015·Biochemistry·Mark G Teese, Dieter Langosch
Sep 17, 2013·Biochimica Et Biophysica Acta·Konstantin S MineevAlexander S Arseniev
May 18, 2011·Biochimica Et Biophysica Acta·K S MineevA S Arseniev
Apr 12, 2011·Biochimica Et Biophysica Acta·Dror E WarschawskiIsabelle Marcotte
Aug 4, 2011·Molecular Membrane Biology·Simon G Patching
Mar 21, 2015·Biochimica Et Biophysica Acta·Michael Stangl, Dirk Schneider
Jun 23, 2015·Annual Review of Biophysics·Lucy R Forrest
Jan 27, 2015·Annual Review of Biochemistry·Erika KovacsJohn Kuriyan
Jan 21, 2014·Biochimica Et Biophysica Acta·Qingxin LiCongBao Kang
Nov 15, 2011·Structure·Phillip J Stansfeld, Mark S P Sansom

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.