Spatial summation of heat pain within and across dermatomes in fibromyalgia patients and pain-free subjects

Pain
Roland StaudDonald D Price

Abstract

The mechanisms of spatial summation of pain (SSP) include pain coding dependent on impulse frequency and the number of recruited central neurons. However, SSP may also be influenced by pain inhibitory mechanisms, such as diffuse noxious inhibitory controls. Abnormal interactions between pain inhibitory mechanisms and SSP may be relevant for chronic pain conditions such as fibromyalgia (FM) and may help explain why widespread pain is characteristic for this chronic pain syndrome. The present study was designed to determine the difference of thermal SSP in the upper extremities between FM and normal control (NC) subjects, particularly within and across dermatomes of the hand. Fourteen NC and 19 FM subjects were enrolled in this study. SSP testing sessions involved immersion of each individual fingertip as well as stepwise immersion of the fingers, hands, and forearms in a hot water bath (46 degrees Celsius) for 5s and 20s. In addition, immersion of several fingertips across dermatome C(7)-C(8) was compared to progressive immersion of the index finger (dermatome C(7)). These experiments demonstrated significant spatial summation of heat-induced pain in both FM and NC subjects. SSP was most extensive within the fingers, and became ...Continue Reading

References

Jan 1, 1991·Journal of Neurophysiology·R C CoghillD J Mayer
Jul 1, 1980·Journal of Neurophysiology·S Chery-Croze, R Duclaux
Jan 1, 1995·Somatosensory & Motor Research·S LautenbacherF Strian
Jul 1, 1996·Pain·R Defrin, G Urca
Sep 26, 1997·The Clinical Journal of Pain·S Lautenbacher, G B Rollman
Jan 1, 1997·Somatosensory & Motor Research·J Nielsen, L Arendt-Nielsen
Mar 2, 2002·Brain : a Journal of Neurology·Ruth DefrinGideon Urca
Nov 1, 1958·Journal of Applied Physiology·L C GREENE, J D HARDY
Sep 27, 1958·Nature·K R HALL
Dec 9, 2003·Pain·Ruth DefrinChava Peretz
Sep 1, 2004·The Journal of Pain : Official Journal of the American Pain Society·Roland StaudCharles J Vierck
Jul 1, 1940·The Journal of Clinical Investigation·J D HardyH Goodell
Oct 27, 2007·Regional Anesthesia and Pain Medicine·Lars Arendt-NielsenAsbjørn Mohr Drewes
Nov 8, 2007·The British Journal of Dermatology·Y IshiujiG Yosipovitch

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Citations

Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kirsty BannisterAnthony H Dickenson
Feb 21, 2007·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Catherine E KerrChristopher I Moore
Jan 8, 2010·Journal of Palliative Medicine·Mark John StevensAndrew M Broadbent
Jan 3, 2012·The Clinical Journal of Pain·Kate S SuttonSusan Chamberlain
Sep 18, 2009·Journal of Neurophysiology·Alexandre S Quevedo, Robert C Coghill
Aug 10, 2007·Expert Opinion on Pharmacotherapy·Roland Staud
Nov 19, 2011·Best Practice & Research. Clinical Rheumatology·Roland Staud
Oct 27, 2009·The Journal of Pain : Official Journal of the American Pain Society·Mark D BishopMichael E Robinson
Aug 4, 2009·Rheumatic Diseases Clinics of North America·Roland Staud
Apr 28, 2009·Progress in Neurobiology·Ryan K Butler, David P Finn
Jul 3, 2007·Best Practice & Research. Clinical Rheumatology·Roland Staud
Dec 6, 2006·The Journal of Pain : Official Journal of the American Pain Society·Alexandre S Quevedo, Robert C Coghill
Oct 18, 2008·European Journal of Pain : EJP·HongLing NieLars Arendt-Nielsen
Oct 9, 2015·Clinical Reviews in Allergy & Immunology·Andrea T Borchers, M Eric Gershwin
Aug 26, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Tim Alex LindskouThomas Graven-Nielsen
Dec 3, 2016·The Journal of Pain : Official Journal of the American Pain Society·C Richard Chapman, Charles J Vierck
Feb 15, 2017·Pain·Alexandre S QuevedoRobert C Coghill
Aug 30, 2017·Scandinavian Journal of Pain·Michele Curatolo
Feb 18, 2012·European Journal of Pain : EJP·M BurgmerE Pogatzki-Zahn
Dec 22, 2007·Somatosensory & Motor Research·Stefan LautenbacherGary B Rollman
Jan 8, 2020·Experimental Brain Research·Mark HollinsDillon Taylor
Apr 18, 2014·Journal of Pharmacological Sciences·Nicoletta GaleottiCarla Ghelardini
Nov 7, 2017·European Journal of Pain : EJP·L Arendt-NielsenA Mohr Drewes
Dec 11, 2019·International Journal of Molecular Sciences·Franck AbyPascal Fossat
Jan 16, 2021·Pain·Wacław M AdamczykKerstin Luedtke
Jul 1, 2021·Journal of Neurophysiology·Mauricio Carlos HenrichOle Kæseler Andersen

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