Spatial synaptic integration in Purkinje cell dendrites

Journal of Physiology, Paris
J Midtgaard

Abstract

Synaptic integration occurs within a framework of synaptic connections, and cell type-specific, intrinsic and transmitter-gated ion channels. These components are differentially distributed over the somato-dendritic membrane. Recent results from Purkinje cells and pyramidal cells exemplify some of these mechanisms of spatial synaptic integration. This paper focusses on the cerebellar Purkinje cell. In these neurons, the amplitude and distribution of single climbing fibre and parallel fibre EPSP-evoked Ca2+ influx were regulated by the transient outward, IA-like current in the distal (spiny) dendrites. The synaptically evoked Ca2+ influx was graded from a local response involving only a few terminal spiny dendrites to a propagated Ca2+ spike. The climbing fibre-evoked Ca2+ influx in the spiny dendrites was finely graded by parallel fibre-induced depolarization. Climbing fibre and parallel fibre-evoked Ca2+ influx elicited a short lasting afterhyperpolarization that affected subsequent dendritic Ca2+ influx. In addition, inhibitory synaptic input controlled dendritic Ca2+ influx. Interaction between information from different sources along the dendrites is thus controlled by intrinsic potassium conductances and IPSPs. Different e...Continue Reading

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Citations

Mar 21, 2003·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·Jeanette Hellgren KotaleskiKim T Blackwell
May 24, 2006·Brain Research·Desheng Wang, Bernard G Schreurs
Apr 24, 1999·Neuroscience Letters·H TakagiH Suzuki
Mar 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kirsten CaesarMartin Lauritzen
Oct 8, 2005·The Journal of Physiology·Simin KhavandgarKamran Khodakhah
Nov 15, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kirsten CaesarMartin Lauritzen
May 9, 2008·PLoS Computational Biology·Antti SaarinenOlli Yli-Harja
Oct 16, 2004·Journal of Neurophysiology·Giulietta Pinato, Jens Midtgaard

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