Spatial-temporal modeling of the association between air pollution exposure and preterm birth: identifying critical windows of exposure.

Biometrics
Joshua WarrenPeter H Langlois

Abstract

Exposure to high levels of air pollution during the pregnancy is associated with increased probability of preterm birth (PTB), a major cause of infant morbidity and mortality. New statistical methodology is required to specifically determine when a particular pollutant impacts the PTB outcome, to determine the role of different pollutants, and to characterize the spatial variability in these results. We develop a new Bayesian spatial model for PTB which identifies susceptible windows throughout the pregnancy jointly for multiple pollutants (PM(2.5) , ozone) while allowing these windows to vary continuously across space and time. We geo-code vital record birth data from Texas (2002-2004) and link them with standard pollution monitoring data and a newly introduced EPA product of calibrated air pollution model output. We apply the fully spatial model to a region of 13 counties in eastern Texas consisting of highly urban as well as rural areas. Our results indicate significant signal in the first two trimesters of pregnancy with different pollutants leading to different critical windows. Introducing the spatial aspect uncovers critical windows previously unidentified when space is ignored. A proper inference procedure is introduced...Continue Reading

References

Apr 20, 2004·Environmental Pollution·S Ghate, S B Chaphekar
Apr 7, 2005·Environmental Health Perspectives·Radim J SrámMartin Bobak
Jun 9, 2006·Environmental Health Perspectives·Jong-Han LeemCarolyn A Tylenda
Jan 10, 2009·Journal of Pharmacokinetics and Pharmacodynamics·David LunnBeat Neuenschwander
Feb 27, 2009·Journal of Environmental Quality·Vincent R HillJames E Amburgey
Nov 6, 2009·Air Quality, Atmosphere, & Health·Montserrat Fuentes
Jan 26, 2010·Air Quality, Atmosphere, & Health·Sylvia MedinaUNKNOWN on behalf of the Apheis Collaborative Network
Apr 16, 2010·Biostatistics·Roger D Peng, Michelle L Bell

❮ Previous
Next ❯

Citations

Feb 9, 2016·Statistics in Medicine·Joshua L WarrenUNKNOWN National Birth Defects Prevention Study
Jul 16, 2015·American Journal of Respiratory and Critical Care Medicine·Hsiao-Hsien Leon HsuRosalind J Wright
Mar 13, 2015·Biometrics·Luke B SmithMontserrat Fuentes
Aug 16, 2014·Biometrics·Ander Wilson, Brian J Reich
Feb 23, 2013·ISRN Obstetrics and Gynecology·Joshua L WarrenPeter H Langlois
Jan 27, 2015·Environmental Health : a Global Access Science Source·Yin-Hsiu ChenBhramar Mukherjee
Aug 2, 2015·Current Environmental Health Reports·Oliver Robinson, Martine Vrijheid
Dec 18, 2014·American Journal of Epidemiology·Archana P LamichhanePenny Gordon-Larsen
Dec 6, 2017·American Journal of Epidemiology·Ander WilsonBrent A Coull
Sep 12, 2017·International Journal of Environmental Research and Public Health·Kimberly A KaufeldMaria A Terres
Nov 2, 2019·Environmental Health : a Global Access Science Source·Yuri Levin-SchwartzRobert O Wright
Jan 7, 2020·Hypertension·Vanessa Assibey-MensahDavid Q Rich
Feb 15, 2020·Statistics in Medicine·Anny-Claude JosephDavid C Wheeler
Jan 15, 2020·Current Opinion in Pediatrics·Eva TannerElena Colicino
Jan 5, 2019·Environmental Health : a Global Access Science Source·David M StiebMichael Tjepkema
Jan 27, 2019·Current Environmental Health Reports·Jessie P BuckleyJoseph M Braun
Jul 1, 2020·Journal of the Royal Statistical Society. Series C, Applied Statistics·Joshua L WarrenHoward H Chang
May 21, 2019·American Journal of Epidemiology·Paige SheridanTarik Benmarhnia
Feb 3, 2021·Biostatistics·Daniel Mork, Ander Wilson
Jan 4, 2021·Endocrine Reviews·Vasantha PadmanabhanMuraly Puttabyatappa
May 15, 2021·Environmental Research·Kristen M RappazzoThomas J Luben
Jul 1, 2021·Open Forum Infectious Diseases·Gregg S GonsalvesJoshua L Warren

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.