To better understand 'when' and 'where' wideband electrophysiological signals are altered by sedation. We generated animation movies showing electrocorticography (ECoG) amplitudes at eight spectral frequency bands across 1.0-116 Hz, every 0.1s, on three-dimensional surface images of 10 children who underwent epilepsy surgery. We measured the onset, intensity, and variance of each band amplitude change at given nonepileptic regions separately from those at affected regions. We also determined the presence of differential ECoG changes depending on the brain anatomy. Within 20s following injection of midazolam, beta (16-31.5 Hz) and sigma (12-15.5 Hz) activities began to be multifocally augmented with increased variance in amplitude at each site. Beta-sigma augmentation was most prominent within the association neocortex. Augmentation of low-delta activity (1.0-1.5 Hz) was relatively modest and confined to the somatosensory-motor region. Conversely, injection of midazolam induced attenuation of theta (4.0-7.5 Hz) and high-gamma (64-116 Hz) activities. Our observations support the notion that augmentation beta-sigma and delta activities reflects cortical deactivation or inactivation, whereas theta and high-gamma activities contribu...Continue Reading
The effect of diazepam sedation on cerebral glucose metabolism in Alzheimer's disease as measured using positron emission tomography
Changes in the EEG power spectrum after midazolam anaesthesia combined with racemic or S- (+) ketamine
Semilinear canonical correlation applied to the measurement of the electroencephalographic effects of midazolam and flumazenil reversal
Effects of zolpidem on local cerebral glucose metabolism during non-REM sleep in normal volunteers: a positron emission tomography study
Clinical relevance of quantified intracranial interictal spike activity in presurgical evaluation of epilepsy
The thalamus as the generator and modulator of EEG alpha rhythm: a combined PET/EEG study with lorazepam challenge in humans
An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
Effects of age and emotionality on the effectiveness of midazolam administered preoperatively to children
Cortical glucose metabolism correlates negatively with delta-slowing and spike-frequency in epilepsy associated with tuberous sclerosis.
In vivo animation of auditory-language-induced gamma-oscillations in children with intractable focal epilepsy.
Short-latency median-nerve somatosensory-evoked potentials and induced gamma-oscillations in humans.
Neural correlates of high-gamma oscillations (60-200 Hz) in macaque local field potentials and their potential implications in electrocorticography
Functional connectivity in the default network during resting state is preserved in a vegetative but not in a brain dead patient.
Neural representations of individual stimuli in humans revealed by gamma-band electrocorticographic activity.
Quantitative brain surface mapping of an electrophysiologic/metabolic mismatch in human neocortical epilepsy.
Dynamic time course of typical childhood absence seizures: EEG, behavior, and functional magnetic resonance imaging.
Spontaneous and visually driven high-frequency oscillations in the occipital cortex: intracranial recording in epileptic patients
Olfactory hallucinations elicited by electrical stimulation via subdural electrodes: effects of direct stimulation of olfactory bulb and tract.
High-frequency neural activity and human cognition: past, present and possible future of intracranial EEG research.
Recursive grid partitioning on a cortical surface model: an optimized technique for the localization of implanted subdural electrodes
Brain-Computer Interface (BCI) Applications in Mapping of Epileptic Brain Networks Based on Intracranial-EEG: An Update
Toxicological evaluation of convulsant and anticonvulsant drugs in human induced pluripotent stem cell-derived cortical neuronal networks using an MEA system
Alprazolam-induced EEG spectral power changes in rhesus monkeys: a translational model for the evaluation of the behavioral effects of benzodiazepines.
Effect of anesthesia on electrocorticography for localization of epileptic focus: Literature review and future directions.
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