Spatial variation of the local tissue oxygen diffusion coefficient measured in situ in the cat retina and cornea

Advances in Experimental Medicine and Biology
H D RohR A Linsenmeier

Abstract

A method for measuring the local oxygen diffusion coefficient (D) in an intact tissue, in situ, in a living cat is described. Values of D were calculated from nonlinear regression analysis of the polarographic (turn-on) transients using a semi-empirical model for the retina and a theoretical one for the cornea. Two types of microelectrodes were employed: in the retina, ones with extremely short recesses; and in the cornea, bare metal needles. The local D in the cat retina was practically homogeneous with a mean of 1.97 +/- 0.11.10(-5) cm2/s, at its body temperature of 37-38 degrees C, 70.6 +/- 3.3 percent of that in isotonic saline at 37 degrees C. In the cat corneal stroma, at its normal temperature in situ of 33 degrees C, D was also virtually homogeneous with a mean of 1.19 +/- 0.20.10(-5) cm2/s, 42.8 +/- 7.3 percent of that in isotonic saline at 37 degrees C.

Citations

Jan 1, 1992·Annals of Biomedical Engineering·D G Buerk, T K Goldstick
Nov 11, 2011·Current Eye Research·Justin WanekMahnaz Shahidi
Aug 30, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Dao-Yi Yu, Stephen J Cringle
Sep 16, 2015·Journal of Mathematical Biology·Paul A RobertsHelen M Byrne
May 15, 2010·Current Eye Research·Shufan WangRobert A Linsenmeier
Jan 23, 2017·Progress in Retinal and Eye Research·Robert A Linsenmeier, Hao F Zhang
Jun 16, 2011·Neurochemistry International·Ricardo M SantosRui M Barbosa

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