PMID: 9551180Jan 1, 1997Paper

Spatially distinct domains of cell behavior in the zebrafish organizer region

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
L A D'Amico, Mark S Cooper

Abstract

To determine the sequence of cell behaviors that is involved in the morphogenesis of the zebrafish organizer region, we have examined the dorsal marginal zone of vitally stained zebrafish embryos using time-lapse confocal microscopy. During the late-blastula stage, the zebrafish dorsal marginal zone segregates into several cellular domains, including a group of noninvoluting, highly endocytic marginal (NEM) cells. The NEM cell cluster, which lies in a superficial location of the dorsal marginal zone, is composed of both enveloping layer cells and one or two layers of underlying deep cells. The longitudinal position of this cellular domain accurately predicts the site of embryonic shield formation and occupies a homologous location to the organizer epithelium in Xenopus laevis. At the onset of gastrulation, deep cells underneath the superficial NEM cell domain undergo involution to form the nascent hypoblast of the embryonic shield. Deep cells within the NEM cell cluster, however, do not involute during early shield formation, but instead move in front of the blastoderm margin to form a loose mass of cells called forerunner cells. Forerunner cells coalesce into a wedge-shaped mass during late gastrulation and eventually become o...Continue Reading

References

Oct 1, 1995·Current Opinion in Genetics & Development·W Driever
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·P S Klein, D A Melton

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Citations

Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·E GillandS E Webb
Apr 3, 2008·Human Molecular Genetics·Marwan K TayehDiane C Slusarski
Jan 24, 2007·American Journal of Surgery·Benjamin ChiangSufan Chien
Oct 17, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Noriko OkabeRebecca D Burdine
Dec 6, 2008·Seminars in Cell & Developmental Biology·Martin BlumPhilipp Vick
Dec 19, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L A D'Amico, M S Cooper
Dec 19, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S J Du, M Dienhart
Feb 6, 2008·Zebrafish·Clarissa A HenryMark S Cooper
Oct 15, 2018·Journal of Cellular Physiology·Jingyun LiXiaohua Dong
Feb 8, 2007·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Mark S Cooper, Valerie C Virta
Apr 7, 2017·Korean Circulation Journal·Hajime FukuiNaoki Mochiuzki

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