Spatially Periodic Activation Patterns of Retrosplenial Cortex Encode Route Sub-spaces and Distance Traveled

Current Biology : CB
Andrew S Alexander, Douglas A Nitz

Abstract

Traversal of a complicated route is often facilitated by considering it as a set of related sub-spaces. Such compartmentalization processes could occur within retrosplenial cortex, a structure whose neurons simultaneously encode position within routes and other spatial coordinate systems. Here, retrosplenial cortex neurons were recorded as rats traversed a track having recurrent structure at multiple scales. Consistent with a major role in compartmentalization of complex routes, individual retrosplenial cortex (RSC) neurons exhibited periodic activation patterns that repeated across route segments having the same shape. Concurrently, a larger population of RSC neurons exhibited single-cycle periodicity over the full route, effectively defining a framework for encoding of sub-route positions relative to the whole. The same population simultaneously provides a novel metric for distance from each route position to all others. Together, the findings implicate retrosplenial cortex in the extraction of path sub-spaces, the encoding of their spatial relationships to each other, and path integration.

References

Oct 1, 1978·Cognitive Psychology·A Stevens, P Coupe
Jan 1, 1986·Cognitive Psychology·T P McNamara
May 1, 1985·Memory & Cognition·S C Hirtle, J Jonides
Nov 1, 1995·The European Journal of Neuroscience·S I WienerA Berthoz
Apr 20, 1999·Neuroreport·B G Cooper, S J Mizumori
Feb 1, 2005·Neuroscience·N Schmitzer-TorbertA D Redish
Apr 23, 2005·The Quarterly Journal of Experimental Psychology. B, Comparative and Physiological Psychology·Guillermo R EsberJohn M Pearce
Jun 21, 2005·Nature·Torkel HaftingEdvard I Moser
Nov 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam Johnson, A David Redish
Jul 5, 2008·Science·Kirsten Brun KjelstrupMay-Britt Moser
Sep 6, 2008·Science·Eva PastalkovaGyörgy Buzsáki
Feb 20, 2009·Frontiers in Integrative Neuroscience·Matthijs A A van der Meer, A David Redish
Sep 15, 2009·Nature Neuroscience·Dori DerdikmanEdvard I Moser
Feb 5, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sébastien RoyerGyörgy Buzsáki
Apr 16, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin J ClarkJeffrey S Taube
Sep 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Annabelle C SingerLoren M Frank
Nov 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rebecca KnightKathryn Jeffery
Mar 1, 2012·Neuron·Jonathan R WhitlockEdvard I Moser
May 17, 2012·Learning & Memory·Kishan GuptaMichael E Hasselmo
Apr 19, 2013·Nature·Brad E Pfeiffer, David J Foster
Aug 16, 2013·Cerebral Cortex·Hugo J SpiersKathryn J Jeffery
Oct 4, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rafał CzajkowskiMenno P Witter
Dec 7, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Katherine R SherrillChantal E Stern
Apr 18, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aaron A WilberBruce L McNaughton
Oct 6, 2014·Nature Neuroscience·Steven A MarchetteRussell A Epstein
Nov 25, 2014·Nature Neuroscience·Zahra M AghajanMayank R Mehta
Apr 7, 2015·Current Biology : CB·Jonathan F MillerJoshua Jacobs
Apr 29, 2015·Current Biology : CB·Francis CarpenterCaswell Barry
Jul 7, 2015·Nature Neuroscience·Andrew S Alexander, Douglas A Nitz
Jul 21, 2015·Hippocampus·Roddy M GrievesPaul A Dudchenko
Nov 6, 2015·Neuron·Benjamin J KrausHoward Eichenbaum
Nov 21, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elizabeth R ChrastilChantal E Stern
May 12, 2016·Human Brain Mapping·Martin WienerJames C Thompson
Nov 18, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrej Bicanski, Neil Burgess

❮ Previous
Next ❯

Citations

Jan 9, 2018·Journal of Cognitive Neuroscience·Stephen D Auger, Eleanor A Maguire
Aug 18, 2017·Journal of Neurophysiology·Roddy M GrievesPaul A Dudchenko
Feb 15, 2018·Journal of Neurophysiology·James R HinmanMichael E Hasselmo
Mar 15, 2018·Journal of Neurophysiology·Shahaf Weiss, Dori Derdikman
Jul 29, 2018·The European Journal of Neuroscience·Nicola Solari, Balázs Hangya
May 4, 2018·Hippocampus·Kenneth Kay, Loren M Frank
Nov 2, 2019·Cerebral Cortex·Choijiljav ChinzorigHisao Nishijo
Apr 7, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·HaoRan ChangBruce L McNaughton
Sep 5, 2018·ELife·Andrej Bicanski, Neil Burgess
Sep 18, 2018·Brain and Neuroscience Advances·Anna S MitchellAndrew J D Nelson
Feb 8, 2019·The Journal of Experimental Biology·Philippe GaussierBruno Poucet
Mar 5, 2020·Science Advances·Andrew S AlexanderMichael E Hasselmo
Jun 30, 2019·Journal of Cognitive Neuroscience·Holger DannenbergMichael E Hasselmo
Sep 11, 2019·ELife·Michael PeerShahar Arzy
Mar 11, 2020·ELife·Lukas F FischerMark T Harnett
Jul 18, 2018·Proceedings of the National Academy of Sciences of the United States of America·Dun MaoBruce L McNaughton
Oct 11, 2020·Nature Communications·Michel Thiebaut de SchottenParashkev Nachev
Jan 3, 2021·Cerebral Cortex·Adam M P MillerDavid M Smith
Feb 29, 2020·Current Biology : CB·Chia-Hsuan WangJames J Knierim
Apr 22, 2020·Current Biology : CB·Ryan Place, Douglas A Nitz
Jan 20, 2021·Cell Research·Xiaoyang Long, Sheng-Jia Zhang
Dec 10, 2020·Brain and Neuroscience Advances·Andrew S AlexanderMichael E Hasselmo
May 6, 2019·Neuroscience and Biobehavioral Reviews·Travis P ToddDavid J Bucci
Apr 18, 2020·Current Biology : CB·Jacob M OlsonDouglas A Nitz
Apr 21, 2021·The Journal of Physiology·Mengxuan GaoYuji Ikegaya
Nov 30, 2020·Trends in Cognitive Sciences·Michael PeerRussell A Epstein
Dec 4, 2021·Science Advances·Lea-Maria SchmittJonas Obleser

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.