Spatially resolved kinetics of skeletal muscle exercise response and recovery with multiple echo diffusion tensor imaging (MEDITI): a feasibility study

Magma
Eric E SigmundJ Bencardino

Abstract

We describe measurement of skeletal muscle kinetics with multiple echo diffusion tensor imaging (MEDITI). This approach allows characterization of the microstructural dynamics in healthy and pathologic muscle. In a Siemens 3-T Skyra scanner, MEDITI was used to collect dynamic DTI with a combination of rapid diffusion encoding, radial imaging, and compressed sensing reconstruction in a multi-compartment agarose gel rotation phantom and within in vivo calf muscle. An MR-compatible ergometer (Ergospect Trispect) was employed to enable in-scanner plantar flexion exercise. In a HIPAA-compliant study with written informed consent, post-exercise recovery of DTI metrics was quantified in eight volunteers. Exercise response of DTI metrics was compared with that of T2-weighted imaging and characterized by a gamma variate model. Phantom results show quantification of diffusivities in each compartment over its full dynamic rotation. In vivo calf imaging results indicate larger radial than axial exercise response and recovery in the plantar flexion-challenged gastrocnemius medialis (fractional response: nT2w = 0.385 ± 0.244, nMD = 0.163 ± 0.130, nλ1 = 0.110 ± 0.093, nλrad = 0.303 ± 0.185). Diffusion and T2-weighted response magnitudes were ...Continue Reading

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Citations

Mar 8, 2020·Journal of Magnetic Resonance Imaging : JMRI·Melissa T HooijmansGustav J Strijkers
Jul 10, 2019·Journal of Magnetic Resonance Imaging : JMRI·Rajiv G MenonRavinder R Regatte
Aug 15, 2021·Journal of Magnetic Resonance Imaging : JMRI·Erin K EnglundEric E Sigmund

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