Spatio-temporal distribution of the adherens junction-associated molecules vinculin and talin in the early avian embryo

Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists
J L Duband, J P Thiery

Abstract

To gain an insight into the possible involvement of the cytoskeletal components and cellular junctions in morphogenetic processes during development, we have studied the spatio-temporal distribution of two major adherens-junction-associated molecules, vinculin and talin, during avian embryogenesis, using immunofluorescence microscopy and immunoblotting. Both molecules were detected at very early stages during morphogenesis and were found in a wide variety of tissues deriving from the three primary germ layers. A number of tissues, including smooth and striated muscles, endothelia, and some hemopoietic precursors, expressed vinculin and talin at especially high levels either transiently or permanently. Conversely, only a few cell types, e.g., circulating erythrocytes and neurones in the central nervous system lacked or expressed them at very low levels. In addition, expression of vinculin and talin was in some cases modulated in connection with morphological rearrangements of tissues. In particular, they were transiently enhanced in restricted areas of the ectoderm and endoderm undergoing extensive foldings. However, other morphogenetic events such as local disruptions of epithelia were not accompanied by extensive modifications...Continue Reading

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Citations

Nov 23, 2006·BMC Developmental Biology·Mira D LozykMichal Opas
Jul 13, 2004·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Balby GonzálezMaria Eugenia Mendoza-Garrido
Oct 26, 2016·Stem Cells·Gaurav KaushikAli Khademhosseini
Oct 31, 2000·Microscopy Research and Technique·J StutzmannP Simon-Assmann

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