Spatio-temporal dynamics of cortical drive to human subthalamic nucleus neurons in Parkinson's disease

Neurobiology of Disease
Andrew SharottAndreas K Engel

Abstract

Pathological synchronisation of beta frequency (12-35Hz) oscillations between the subthalamic nucleus (STN) and cerebral cortex is thought to contribute to motor impairment in Parkinson's disease (PD). For this cortico-subthalamic oscillatory drive to be mechanistically important, it must influence the firing of STN neurons and, consequently, their downstream targets. Here, we examined the dynamics of synchronisation between STN LFPs and units with multiple cortical areas, measured using frontal ECoG, midline EEG and lateral EEG, during rest and movement. STN neurons lagged cortical signals recorded over midline (over premotor cortices) and frontal (over prefrontal cortices) with stable time delays, consistent with strong corticosubthalamic drive, and many neurons maintained these dynamics during movement. In contrast, most STN neurons desynchronised from lateral EEG signals (over primary motor cortices) during movement and those that did not had altered phase relations to the cortical signals. The strength of synchronisation between STN units and midline EEG in the high beta range (25-35Hz) correlated positively with the severity of akinetic-rigid motor symptoms across patients. Together, these results suggest that sustained s...Continue Reading

Citations

Jul 26, 2019·Proceedings of the National Academy of Sciences of the United States of America·Hayriye CagnanAndrew Sharott
Apr 1, 2020·PLoS Computational Biology·Jyotika BahugunaArvind Kumar
Jul 9, 2020·Proceedings of the National Academy of Sciences of the United States of America·Aviv D Mizrahi-KligerHagai Bergman
Sep 11, 2019·Brain : a Journal of Neurology·Nicoló G PozziIoannis U Isaias
Dec 24, 2020·Trends in Cognitive Sciences·Jonathan J Cannon, Aniruddh D Patel
Dec 18, 2019·Neuroscience and Biobehavioral Reviews·Loïc DammBenoît Bardy
Jan 11, 2020·Neurobiology of Disease·Magdalena K BaaskeChristian K E Moll

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Methods Mentioned

BETA
SMA

Software Mentioned

CircStat
Neurospec
MATLAB

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