DOI: 10.1101/475335Nov 20, 2018Paper

Spatio-temporal dynamics of dengue in Brazil: seasonal travelling waves and determinants of regional synchrony

BioRxiv : the Preprint Server for Biology
Mikhail ChurakovSimon Cauchemez

Abstract

Dengue continues to be the most important vector-borne viral disease globally and in Brazil, where more than 1.4 million cases and over 500 deaths were reported in 2016. Mosquito control programmes and other interventions have not stopped the alarming trend of increasingly large epidemics in the past few years. Here, we analyzed monthly dengue cases reported in Brazil between 2001 and 2016 to better characterize the key drivers of dengue epidemics. Spatio-temporal analysis revealed recurring travelling waves of disease occurrence. Using wavelet methods, we characterised the average seasonal pattern of dengue in Brazil, which starts in the western states of Acre and Rondônia, then travels eastward to the coast before reaching the northeast of the country. Only two states in the north of Brazil (Roraima and Amapá) did not follow the countrywide pattern and had inconsistent timing of dengue epidemics throughout the study period. We also explored epidemic synchrony and timing of annual dengue cycles in Brazilian regions. Using gravity style models combined with climate factors, we showed that both human mobility and vector ecology contribute to spatial patterns of dengue occurrence. This study offers a characterization of the spati...Continue Reading

Related Concepts

Arboviruses
Dengue Fever
Genetic Vectors
Culicidae
Spatial Distribution
Virus Diseases
Epidemic Disease
Patterns
Drivers of Vehicles
Analysis

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