Spatio-temporal electrical stimuli shape behavior of an embodied cortical network in a goal-directed learning task.

Journal of Neural Engineering
Douglas J BakkumSteve M Potter

Abstract

We developed an adaptive training algorithm, whereby an in vitro neocortical network learned to modulate its dynamics and achieve pre-determined activity states within tens of minutes through the application of patterned training stimuli using a multi-electrode array. A priori knowledge of functional connectivity was not necessary. Instead, effective training sequences were continuously discovered and refined based on real-time feedback of performance. The short-term neural dynamics in response to training became engraved in the network, requiring progressively fewer training stimuli to achieve successful behavior in a movement task. After 2 h of training, plasticity remained significantly greater than the baseline for 80 min (p-value<0.01). Interestingly, a given sequence of effective training stimuli did not induce significant plasticity (p-value=0.82) or desired behavior, when replayed to the network and no longer contingent on feedback. Our results encourage an in vivo investigation of how targeted multi-site artificial stimulation of the brain, contingent on the activity of the body or even of the brain itself could treat neurological disorders by gradually shaping functional connectivity.

References

Nov 1, 1991·Pharmacology, Biochemistry, and Behavior·H M EmrichW Hanisch
May 1, 1991·Journal of Studies on Alcohol·W F GabrielliJ R Wilson
Jan 1, 1994·International Review of Neurobiology·A P Georgopoulos
Aug 20, 1993·Science·M A Wilson, B L McNaughton
Jul 22, 1998·Epilepsia·S C Schachter, C B Saper
Oct 15, 1998·Nature Medicine·J MartinerieF J Varela
May 29, 2000·Brain : a Journal of Neurology·M JahanshahiP Limousin-Dowsey
Jun 3, 2000·Stroke; a Journal of Cerebral Circulation·J LiepertC Weiller
Apr 3, 2001·Annual Review of Neuroscience·G Bi, M Poo
Sep 21, 2001·Journal of Neuroscience Methods·S M Potter, T B DeMarse
May 10, 2002·Quarterly Reviews of Biophysics·Shimon Marom, Goded Shahaf
Oct 19, 2002·Journal of Neuroscience Methods·Daniel A Wagenaar, Steve M Potter
Nov 14, 2002·Brain : a Journal of Neurology·Heidi Johansen-BergPaul M Matthews
Nov 5, 2003·Nature Reviews. Neuroscience·Wei Zhang, David J Linden
Dec 6, 2003·Learning & Memory·Gaël Daoudal, Dominique Debanne
Aug 25, 2004·Journal of Neuroscience Methods·Daniel A WagenaarSteve M Potter
Jan 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel A WagenaarSteve M Potter
Mar 8, 2005·Neuron·Helen S MaybergSidney H Kennedy
Mar 12, 2005·IEEE Transactions on Bio-medical Engineering·Maria Elisabetta RuaroVincent Torre
Apr 20, 2005·Annals of the New York Academy of Sciences·Bruce H Dobkin
May 7, 2005·Journal of Neural Engineering·Daniel A Wagenaar, Steve M Potter
Oct 4, 2005·Journal of Bioscience and Bioengineering·Fabrice O MorinEiichi Tamiya
Nov 12, 2005·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·R Douglas Fields
Feb 9, 2006·BMC Neuroscience·Daniel A WagenaarSteve M Potter
Mar 18, 2006·Neuron·Tomoko IshibashiR Douglas Fields
Jun 17, 2006·Annual Review of Neuroscience·Joel S Perlmutter, Jonathan W Mink
Jun 23, 2006·Journal of Neuroengineering and Rehabilitation·He HuangJiping He
Oct 24, 2006·Nature·Andrew JacksonEberhard E Fetz
Oct 28, 2006·Journal of Negative Results in Biomedicine·Daniel A WagenaarSteve M Potter
Feb 15, 2007·Muscle & Nerve·Lynne R Sheffler, John Chae
Apr 6, 2007·Journal of Neural Engineering·A L Jensen, D M Durand
May 15, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Naofumi UesakaNobuhiko Yamamoto
Aug 19, 2007·Acta Neurochirurgica. Supplement·V Visser-Vandewalle
Sep 13, 2007·The Neurologist·Drew S Kern, Rajeev Kumar
Oct 12, 2007·Physical Biology·Radhika MadhavanSteve M Potter
Mar 29, 2008·PLoS Computational Biology·Zenas C ChaoSteve M Potter
Jun 28, 2008·Autonomous Robots·Thomas B DemarseSteve M Potter

❮ Previous
Next ❯

Citations

Nov 1, 2012·Bulletin of Experimental Biology and Medicine·A L SukhanovaK V Anokhin
Apr 9, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jill M ZemianekThomas B Shea
Jul 17, 2013·Journal of Neuroscience Methods·Tatsuya HagaKunihiko Mabuchi
May 23, 2012·PLoS Computational Biology·Julia H DownesSlawomir J Nasuto
Jun 3, 2010·Journal of Visualized Experiments : JoVE·Chadwick M HalesSteve M Potter
Feb 3, 2016·Frontiers in Systems Neuroscience·H Isaac ChenDouglas H Smith
Dec 12, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jill M ZemianekThomas B Shea
Aug 22, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jill M ZemianekThomas B Shea
Oct 30, 2008·Journal of Neuroscience Methods·Alessandro MaccioneMichela Chiappalone
Oct 18, 2015·Brain Research Bulletin·Alessandro Napoli, Iyad Obeid
Jan 27, 2012·The European Journal of Neuroscience·Antonny CzarneckiJürg Streit
May 31, 2011·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Dimitris XydasKevin Warwick
Apr 12, 2016·Frontiers in Neuroscience·Nathaniel J KillianJelena Vukasinovic
Oct 11, 2017·ELife·Milos RadivojevicDouglas J Bakkum
Feb 16, 2012·Journal of Neural Engineering·Ling WangEnric Claverol-Tinturé
Jun 22, 2017·Annual Review of Biomedical Engineering·Michael LevinJoshua M Finkelstein
Mar 31, 2016·Journal of Biomolecular Screening·Ellese CotterillTimothy J Shafer
Oct 10, 2018·Frontiers in Neuroscience·Min D Tang-SchomerSabato Santaniello
Dec 2, 2018·Frontiers in Neuroinformatics·Vyacheslav Demin, Dmitry Nekhaev
Mar 17, 2020·Frontiers in Neuroscience·Sergey A LobovVictor B Kazantsev
Nov 13, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Pieter Laurens BaljonSergio Martinoia
May 1, 2021·Sensors·Sergey A LobovVictor B Kazantsev

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain-Computer Interface

A brain-computer interface, also known as a brain-machine interface, is a bi-directional communication pathway between an external device and a wired brain. Here is the latest research on this topic.