Spatio-temporal expression patterns of steroidogenic acute regulatory protein (StAR) during follicular development in the rat ovary

Endocrinology
T Ronen-FuhrmannJoseph Orly

Abstract

The steroidogenic acute regulatory protein (StAR) is a vital mitochondrial protein that is indispensable for the synthesis of steroid hormones in the steroidogenic cells of the adrenal cortex and the gonads. Recent studies have shown that StAR enhances the conversion of the substrate for all steroid hormones, cholesterol, into pregnenolone, probably by facilitating cholesterol entry into the inner compartment of the mitochondria where the steroidogenic cytochrome P450scc complex resides. To study the potential of StAR to affect ovarian steroidogenesis during follicular development, we examined the time-dependent expression of StAR protein and messenger RNA in PMSG/human CG (hCG)-treated immature rats. Western blot analyses and immunohistochemical and RT-PCR methodologies have revealed a biphasic expression of StAR in the ovaries responding to hormones. The first peak of StAR expression was generated by PMSG administration and lasted for 24 h. Furthermore, it was restricted to the entire network of the ovarian secondary interstitial tissue, as well as to a fewer scattered theca-interna cells. The second burst of StAR expression was observed in response to the LH surge, as simulated by hCG. This time, StAR was expressed in the en...Continue Reading

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Citations

Aug 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Tehnaz N ParakhJohn H Nilson
Mar 27, 2009·Molecular Human Reproduction·Pulak R MannaDouglas M Stocco
Oct 10, 2009·Molecular Human Reproduction·Jaeyeon KimMilan K Bagchi
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Dec 26, 2003·Comptes rendus biologies·Alexandra C ProvostMarc Abitbol
Jan 16, 2007·Molecular and Cellular Endocrinology·Zvi GranotJoseph Orly
May 5, 2009·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·G SreenivasuluB Senthilkumaran
Oct 16, 2010·Reproduction in Domestic Animals = Zuchthygiene·S EbelingB Meinecke
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Sep 20, 2000·Biology of Reproduction·E V SolovyevaA Tsafriri
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