Spatio-temporal pattern of programmed cell death in the developing Drosophila optic lobe

Development, Growth & Differentiation
Yu ToganeHidenobu Tsujimura

Abstract

A large number of cells die via programmed cell death during the normal development of the Drosophila optic lobe. In this study, we report the precise spatial and temporal pattern of cell death in this organ. Cell death in the developing optic lobe occurs in two distinct phases. The first phase extends from the start of metamorphosis to the mid-pupal stage. During this phase, a large number of cells die in the optic lobe as a whole, with a peak of cell death at an early pupal stage in the lamina and medulla cortices and the region of the T2/T3/C neurons, and a smaller number of dead cells observed in the lobula plate cortex. The second phase extends from the mid-pupal stage to eclosion. Throughout this period, a small number of dying cells can be observed, with a small peak at a late pupal stage. Most of the dying cells are neurons. During the first phase, dying cells are distributed in specific patterns in cortices. The lamina cortex contains two distinct clusters of dying cells; the medulla cortex, four clusters; the lobula plate cortex, one cluster; and the region of the T2/T3/C neurons, one cluster. Many of the clusters maintain their distinct positions in the optic lobe but others extend the region they cover during develo...Continue Reading

References

Nov 1, 1992·Journal of Neurobiology·J W TrumanS Robinow
Jul 1, 1990·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·O Aït-AhmedM Capri
Jan 1, 1991·Annual Review of Neuroscience·R W Oppenheim
Jan 1, 1983·Cell and Tissue Research·K F Fischbach, I Lyly-Hünerberg
Jan 1, 1997·Insect Biochemistry and Molecular Biology·J D Dai, L I Gilbert
Feb 17, 2000·The EMBO Journal·P MeierG I Evan
Jun 17, 2000·Trends in Neurosciences·C Y KuanP Rakic
Jan 4, 2001·Cell Death and Differentiation·E H Baehrecke
Jan 11, 2002·Developmental Biology·K J SeppV J Auld
Sep 26, 2002·Developmental Biology·Cheng-Yu LeeEric H Baehrecke
Jan 1, 2003·The Journal of Comparative Neurology·Claude NassifVolker Hartenstein
Jan 1, 2003·The Journal of Comparative Neurology·Karin DumstreiVolker Hartenstein
Aug 23, 2003·Cell Death and Differentiation·E H Baehrecke
Feb 1, 1965·Journal of Insect Physiology·R A LOCKSHIN, C M WILLIAMS
Dec 12, 2003·Development·Damali N Martin, Eric H Baehrecke
Apr 16, 2004·Current Biology : CB·Ryan J WattsLiqun Luo
Nov 11, 2005·Nature·Ken-Ichi KimuraDaisuke Yamamoto
Jan 3, 2006·Current Opinion in Neurobiology·Marc R Freeman
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·K F Fischbach, M Heisenberg
Dec 14, 2006·Development·Ana Rogulja-OrtmannGerhard M Technau
Feb 8, 2008·Genesis : the Journal of Genetics and Development·Damon T Page, Birgitta Olofsson
Mar 12, 2008·Neuron Glia Biology·Carole Chotard, Iris Salecker
Aug 8, 2008·Advances in Experimental Medicine and Biology·Karl-Friedrich Fischbach, Peter Robin Hiesinger

❮ Previous
Next ❯

Citations

Jun 11, 2014·Journal of Neurogenetics·Holger Apitz, Iris Salecker
Feb 25, 2015·Developmental Cell·Yoshifumi Yamaguchi, Masayuki Miura
Apr 23, 2013·Developmental Biology·Makoto SatoYasuhiro Nakai
Feb 24, 2016·The European Journal of Neuroscience·Juliane Melzer, Meike Broemer
Nov 2, 2019·Annals of Clinical and Translational Neurology·Hisato SuzukiToshiki Takenouchi
Nov 21, 2019·Cell Death and Differentiation·Tianqi XuSharad Kumar
Oct 17, 2020·Current Opinion in Insect Science·Gyunghee Lee, Jae H Park

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis