Spatio-temporal stability of pre-treatment 18F-Fludeoxyglucose uptake in head and neck squamous cell carcinomas sufficient for dose painting

Acta Oncologica
J H RasmussenL Specht

Abstract

The pre-treatment 18F-Fludeoxyglucose (FDG) avid subvolume of the tumor has shown promise as a potential target for dose painting in patients with in head and neck squamous cell carcinomas (HNSCC). The purposes of this study are: 1) to assess the pre-treatment spatio-temporal variability of FDG PET/CT target volumes and 2) to assess the impact of this variability on dose distribution in dose painting plans in patients with HNSCC. Thirty patients were enrolled and scanned twice, three days apart, days prior to treatment. Delineation of the FDG avid subvolume of the tumor and lymph nodes on both scans was performed by a specialist in nuclear medicine yielding GTVPET1 and GTVPET2 and segmentation based on SUV iso-contours were constructed yielding two metabolic target volumes, MTV1 and MTV2. Images were co-registered rigidly and dose painting plans with dose escalation up to 82 Gy to GTVPET1 were planned and GTVPET2 was copied from the co-registered images to the dose planning scan. Variation in dose to the target and modeled tumor control probability were assessed as measures of the impact of imaging variations in a dose painting scenario. Twenty-four patients were available for full analysis. The median mismatch between GTVPET1 ...Continue Reading

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Citations

Oct 7, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Eric GrönlundAnders Ahnesjö
Jul 22, 2017·AJR. American Journal of Roentgenology·Reema GoelRathan M Subramaniam
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Nov 1, 2020·Clinical Oncology : a Journal of the Royal College of Radiologists·C PatersonC N Rumley

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