PMID: 9533995Apr 16, 1998Paper

Spatio-temporal working memory and frontal lesions in man

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
C T FerreiraY Agid

Abstract

The delayed-response paradigm is thought to be a marker of the activity of the dorsolateral convexity of primates' prefrontal cortex, as this procedure requires the activation of working memory processes. Although the role of the dorsolateral prefrontal cortex (DLPC) in working memory seems to be well established, much remains to be understood about the processes this structure actually controls: encoding domain-specific information, its retention in short-term memory, its monitoring in working memory, or its selection and retrieval when a specific response program is required. To clarify the role of the DLPC in delayed-response tasks in humans, a set of sequencing paradigms was designed which incorporates the dissociation of (1) spatial and temporal parameters, (2) recall and recognition processes, and (3) the presence or absence of a delay. Performance of a group of patients with DLPC lesions (n = 8) was compared to that of age-matched normal subjects (n = 8). To verify the specificity of the results obtained for the DLPC lesioned patients, the performance of patients with a temporal lobotomy was also studied (n = 10). A significant effect of the delay was observed only in patients with DLPC lesions, affecting both their spat...Continue Reading

Citations

Jan 31, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Wayne M DinnCharles Reilly
Nov 15, 2003·Neuropsychologia·Brigitte StemmerPaul Walter Schönle
Jan 22, 2004·Brain and Cognition·Albert PostmaJack van Honk
Jan 14, 1999·Brain Research Bulletin·M A RogersJ G Phillips
Aug 24, 2001·Schizophrenia Research·J C DreherY Burnod
Aug 15, 2006·Journal of the International Neuropsychological Society : JINS·Albert PostmaRoy P C Kessels
Jan 1, 2003·Psychology and Aging·Sarah E MacPhersonSergio Della Sala
Apr 19, 2008·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Joukje M OostermanErik J A Scherder
Apr 12, 2001·Applied Neuropsychology·R P KesselsE H de Haan
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Feb 12, 2015·The Quarterly Journal of Experimental Psychology : QJEP·Wing-Chee SoMiranda Kit-Yi Wong
Mar 27, 2016·Human Brain Mapping·Amy KuceyeskiMichael O'Dell
Jun 27, 2006·Brain Research·Amishi P JhaNicole R Giuliani
Dec 6, 2000·Brain and Cognition·F MunirJ Wilding
Oct 7, 2005·Cerebral Cortex·Richard Levy, Bruno Dubois
Apr 25, 2007·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Domonick J Wegesin, Yaakov Stern
Nov 23, 2020·Brain and Cognition·Ruiz-Gutiérrez JoséMartín-Monzón Isabel

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