Spatiotemporal Analysis of the Genetic Diversity of Seal Influenza A(H10N7) Virus, Northwestern Europe

Journal of Virology
Rogier BodewesThijs Kuiken

Abstract

Influenza A viruses are major pathogens for humans, domestic animals, and wildlife, and these viruses occasionally cross the species barrier. In spring 2014, increased mortality of harbor seals (Phoca vitulina), associated with infection with an influenza A(H10N7) virus, was reported in Sweden and Denmark. Within a few months, this virus spread to seals of the coastal waters of Germany and the Netherlands, causing the death of thousands of animals. Genetic analysis of the hemagglutinin (HA) and neuraminidase (NA) genes of this seal influenza A(H10N7) virus revealed that it was most closely related to various avian influenza A(H10N7) viruses. The collection of samples from infected seals during the course of the outbreak provided a unique opportunity to follow the adaptation of the avian virus to its new seal host. Sequence data for samples collected from 41 different seals from four different countries between April 2014 and January 2015 were obtained by Sanger sequencing and next-generation sequencing to describe the molecular epidemiology of the seal influenza A(H10N7) virus. The majority of sequence variation occurred in the HA gene, and some mutations corresponded to amino acid changes not found in H10 viruses isolated from...Continue Reading

References

Mar 1, 1992·Microbiological Reviews·R G WebsterY Kawaoka
Jan 1, 1985·Journal of Molecular Evolution·M HasegawaT Yano
Sep 1, 1981·Virology·R G WebsterG Petursson
Jan 1, 1995·The Journal of General Virology·R J CallanV S Hinshaw
May 20, 1999·Molecular Biology and Evolution·H J BandeltA Röhl
Jan 29, 2002·Archives of Virology·E HoffmannD R Perez
May 11, 2006·PLoS Biology·Alexei J DrummondAndrew Rambaut
Mar 1, 2012·Molecular Biology and Evolution·Alexei J DrummondAndrew Rambaut
Apr 21, 2012·Emerging Infectious Diseases·Antonio J RamisThijs Kuiken
Nov 28, 2012·Molecular Biology and Evolution·Mandev S GillMarc A Suchard
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Apr 8, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Marco GrothRoland Zell
Nov 27, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·S ZohariJ F Valarcher
Mar 27, 2015·Emerging Infectious Diseases·Jesper S KrogLars E Larsen
Mar 27, 2015·Emerging Infectious Diseases·Rogier BodewesAlbert D M E Osterhaus

❮ Previous
Next ❯

Citations

Jul 23, 2016·PloS One·Judith M A van den BrandWolfgang Baumgärtner
Oct 5, 2018·Journal of Wildlife Diseases·Lisa YonDolores Gavier-Widén
Apr 19, 2019·Journal of Virology·Minhui GuanXiu-Feng Wan
Aug 21, 2018·Emerging Infectious Diseases·Wendy K JoAlbert Osterhaus
Nov 20, 2019·Emerging Infectious Diseases·Dai-Lun ShinGeorg Herrler
Dec 14, 2017·International Journal of Molecular Sciences·Khristine Kaith S LlorenMin-Suk Song
Oct 9, 2020·Cell Host & Microbe·Sander HerfstRon A M Fouchier

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.