Spatiotemporal changes in metallothionein gene expression during embryogenesis in the wall lizard Podarcis sicula

Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology
Palma SimonielloSilvana Filosa

Abstract

Lizard embryos are nutritionally independent from their environment. During the early phases of oogenesis, the egg prepares for development by storing reserve organelles, proteins, and RNAs sufficient to allow the zygote to transform into a juvenile. This preparation also includes the storage of metallothionein (MT) transcripts. This study investigated the localization of these transcripts by in situ hybridization throughout Podarcis sicula developmental stages. Our data show that MT expression undergoes shifts in both regional and cellular localization. MT transcripts were detected early in the central nervous system, later in tissues implicated in metabolic processes. Results are discussed highlighting differences in lizard embryonic spatial and temporal MT expression compared with piscine, amphibian, and mammalian embryos. We hypothesize that, under natural conditions, the nutritionally closed system represented by the lizard egg protects the developing embryo from an unwanted excess of metals. This mechanism would make MT expression and accumulation in detoxifying organs in developing animals unnecessary until hatching and food intake begins. Conversely, the presence of MT transcripts during brain development may ensure the...Continue Reading

References

Jan 1, 1986·Annual Review of Biochemistry·D H Hamer
Jun 1, 1972·Experimental Cell Research·C Taddei
Jan 1, 1984·Journal of Pediatric Gastroenterology and Nutrition·M P Richards
Dec 1, 1993·Molecular Reproduction and Development·T NomizuB L Vallee
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·R D Palmiter
Apr 1, 2000·Current Opinion in Chemical Biology·M Vasák, D W Hasler
Apr 11, 2001·Mutation Research·I E Dreosti
Jul 27, 2001·Molecular Reproduction and Development·C M MottaS Filosa
May 23, 2002·Cellular and Molecular Life Sciences : CMLS·P CoyleA M Rofe
Sep 12, 2002·Annual Review of Plant Biology·Christopher Cobbett, Peter Goldsbrough
Nov 22, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Michael B Thompson, Brian K Speake
Dec 25, 2002·The Tohoku Journal of Experimental Medicine·Masao Sato, Masuo Kondoh
Jul 16, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Marilisa RiggioRosaria Scudiero
Dec 4, 2003·Mutation Research·Michael P Waalkes
Apr 2, 2004·Medical Electron Microscopy : Official Journal of the Clinical Electron Microscopy Society of Japan·Makoto NaitoTakashi Yamamoto
Nov 25, 2005·Current Medicinal Chemistry·Lu CaiM George Cherian
Jan 25, 2006·Physiology & Behavior·Edward D LevinJonathan H Freedman
Nov 14, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Francesca TrinchellaRosaria Scudiero
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Magdalena Dutsch-WicherekRomana Tomaszewska
Nov 18, 2008·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Suresh Vir Singh Rana
Dec 18, 2008·Chembiochem : a European Journal of Chemical Biology·Stephen G Bell, Bert L Vallee
Aug 22, 2009·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Francesca TrinchellaRosaria Scudiero
Oct 29, 2009·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Palma SimonielloChiara M Motta

❮ Previous
Next ❯

Citations

Oct 5, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Palma SimonielloSilvana Filosa
Aug 22, 2016·Comptes rendus biologies·Palma SimonielloRosaria Scudiero
Oct 9, 2016·Cell and Tissue Research·Stefania TammaroChiara Maria Motta
Jul 30, 2017·International Journal of Molecular Sciences·Rosaria ScudieroPalma Simoniello

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved