Spatiotemporal changes in NFATc4 expression of retinal ganglion cells after light-induced damage

Journal of Molecular Neuroscience : MN
Yue XuXiaoling Liang

Abstract

Nuclear factor of activated T cells, cytoplasmic 4 (NFATc4) is one of the four members of the NFAT family, which were described first as essential components of T cells activation and lately as important regulators for the initiation and coordination of the immune response, including B cells and natural killer cells. Accumulating evidence has demonstrated that NFATc4 exerted a pro-apoptotic effect in the pathogenesis of various experimental central nervous system diseases by upregulating Fas ligand (FasL) levels. However, the function of NFATc4 in the retina is still with limited acquaintance. To investigate whether NFATc4 is involved in retinal neuron apoptosis, we performed a light-induced retinal damage model in adult rats. A significant upregulation of NFATc4 was detected in the retina after light-induced damage by using Western blotting and reverse transcriptase PCR (RT-PCR). Besides this, NFATc4 was observed to be localized mainly in the retinal ganglion cells (RGCs). In addition, the expression patterns of active caspase-3, active caspase-8, and FasL were parallel with that of NFATc4. We also found the co-localization of NFATc4 with active caspase-3 and FasL in RGCs after light exposure. Collectively, we hypothesized tha...Continue Reading

References

Mar 21, 1998·The Journal of Biological Chemistry·C J Holtz-HeppelmannC V Paya
Feb 26, 2000·Annual Review of Genetics·S Nagata
Feb 15, 2003·Trends in Cardiovascular Medicine·David C Hill-EubanksMark T Nelson
May 17, 2003·Circulation Research·Paul B BushdidKatherine E Yutzey
Sep 17, 2003·Genes & Development·Patrick G HoganAnjana Rao
Oct 17, 2003·European Journal of Epidemiology·Redmer van LeeuwenPaulus T V M de Jong
Nov 13, 2004·The Journal of Biological Chemistry·Alessandra B BeneditoAzad Bonni
Jan 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Subramaniam JayanthiJean Lud Cadet
Mar 17, 2006·Journal of Neurochemistry·V S SeyboldP G Mermelstein
Dec 7, 2007·Investigative Ophthalmology & Visual Science·Ming-Hui SunYeou-Ping Tsao
Dec 21, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Tuan Nguyen, Simone Di Giovanni
May 27, 2008·Brain Research Bulletin·Belmira Lara da Silveira Andrade da CostaNeville N Osborne
Sep 27, 2008·Circulation Research·Luis F Santana
Nov 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Martin B WaxDavid J Calkins
Nov 29, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Nikolaos M PharmakakisVassiliki Zolota
May 16, 2009·The Journal of Biological Chemistry·Tuan NguyenSimone Di Giovanni
Oct 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hafiz Mohmmad AbdulChristopher M Norris
Dec 4, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aruna VashishtaMichal Hetman
Mar 1, 2011·Experimental Eye Research·C Galindo-RomeroM Agudo-Barriuso
Jul 12, 2011·Progress in Neurobiology·Elisa BuschiniAlessandro Vercelli
Mar 2, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Eloise HudryBradley T Hyman
Nov 28, 2012·Journal of Neuroinflammation·Matt RutarJan Provis
Feb 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Songhua LiMinghao Jin
Jul 16, 2013·Cellular and Molecular Neurobiology·Lei LiMaohong Cao
Oct 5, 2013·Journal of Molecular Neuroscience : MN·Stephanie C JoachimH Burkhard Dick

❮ Previous
Next ❯

Citations

Mar 26, 2014·Journal of Molecular Neuroscience : MN·Qinmeng ShuGezhi Xu
Oct 22, 2014·Journal of Molecular Neuroscience : MN·Illana Gozes
Apr 29, 2015·Journal of Diabetes Research·Anna V ZetterqvistMaria F Gomez
May 13, 2017·Biochemical and Biophysical Research Communications·Yuki KurauchiKunio Ishii
Aug 21, 2015·PeerJ·Diana PitaEsteban Fernández-Juricic
Apr 21, 2018·Cell Death Discovery·Chloe N ThomasZubair Ahmed
Feb 29, 2020·Cellular and Molecular Neurobiology·Yuan Zhao, Ye Shen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis