Spatiotemporal distribution of small ubiquitin-like modifiers during human placental development and in response to oxidative and inflammatory stress

The Journal of Physiology
D BaczykJ C P Kingdom

Abstract

The post-translational modification of target proteins by SUMOylation occurs in response to stressful stimuli in a variety of organ systems. Small ubiquitin-like modifier (SUMO) isoforms 1-4 have recently been identified in the human placenta, and are upregulated in the major obstetrical complication of pre-eclampsia. This is the first study to characterize the spatiotemporal distribution of SUMO isoforms and their targets during placental development across gestation and in response to stress induced by pre-eclampsia and chorioamnionitis. Keratins were identified as major targets of placental SUMOylation. The interaction with SUMOs and cytoskeletal filaments provides evidence for SUMOylation possibly contributing to underlying dysfunctional trophoblast turnover, which is a hallmark feature of pre-eclampsia. Further understanding the role of individual SUMO isoforms and SUMOylation underlying placental dysfunction may provide a target for a novel therapeutic candidate as an approach for treating pre-eclampsia complicated with placental pathology. SUMOylation is a dynamic, reversible post-translational modification that regulates cellular protein stability and localization. SUMOylation occurs in response to various stressors, in...Continue Reading

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Citations

Mar 7, 2018·The Journal of Physiology·Deanne H Hryciw
May 19, 2018·International Journal of Molecular Sciences·Rajaa AouacheFrancisco Miralles
Oct 19, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·H-M Ivy YuWei Hsu
Jun 22, 2021·Cytoskeleton·Brittany MacTaggart, Anna Kashina

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Methods Mentioned

BETA
confocal microscopy
Protein Assay
transfection
proximity ligation assay
proximity ligation
transgenic

Software Mentioned

Volocity
! Tandem
ProHits
GraphPad
Proteowizard
Quantity One
Prism

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