PMID: 9838209Dec 5, 1998Paper

Spatiotemporal dynamics of clotting and pattern formation in human blood

Biochimica Et Biophysica Acta
F I AtaullakhanovR I Volkova

Abstract

We examined the spatial dynamics of in vitro clot growth in human blood and plasma and found that initially, a clot grows at a constant speed, then abruptly stops and becomes surrounded by an 'inhibition zone' in which coagulation is strongly suppressed. We also observed the formation of 'stratified structures' (target patterns) in which solid layers alternated with liquid plasma. These and other spatial regimes of clotting are explained in terms of two interacting concentration waves propagating without attenuation. The experimental results are consistent with a hypothesis that blood is a bi-excitable medium, a new type of excitable medium.

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Citations

Aug 16, 2000·Thrombosis Research·A V Pokhilko
Feb 21, 2002·Biochimica Et Biophysica Acta·Andrei Yu KondratovichFazoil I Ataullakhanov
Sep 3, 2002·Biochimica Et Biophysica Acta·Mikhail V OvanesovFazly I Ataullakhanov
Jan 25, 2006·Pathophysiology of Haemostasis and Thrombosis·M AnandK R Rajagopal
Mar 12, 2008·Pathophysiology of Haemostasis and Thrombosis·Frank A Greco
Dec 5, 1998·Biochimica Et Biophysica Acta·E I SinauridzeF I Ataullakhanov
Aug 19, 2015·Thrombosis Research·Mikhail A PanteleevFazoil I Ataullakhanov
Jun 2, 2012·Journal of Thrombosis and Haemostasis : JTH·H C HemkerR M W Kremers
Jun 16, 2015·Journal of Theoretical Biology·J PavlovaA Sequeira
Dec 4, 2012·Biophysical Journal·N M DashkevichF I Ataullakhanov
Jul 30, 2015·PloS One·Oleksii S RukhlenkoGeorgy Th Guria
Apr 4, 2013·Expert Review of Hematology·Fazoil I AtaullakhanovMikhail A Panteleev
Jul 23, 2008·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Svetlana G UzlovaGeorgy Th Guria
Jan 11, 2018·The Journal of Cell Biology·Victoria E Deneke, Stefano Di Talia
Nov 13, 2008·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Mikhail V OvanesovFazoil I Ataullakhanov
Jan 25, 2006·Pathophysiology of Haemostasis and Thrombosis·A I Lobanov, T K Starozhilova
Sep 12, 2020·Hämostaseologie·Dmitry Y NechipurenkoMikhail A Panteleev

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