PMID: 8982161Dec 1, 1996Paper

Spatiotemporal dynamics of CREB phosphorylation: transient versus sustained phosphorylation in the developing striatum

Neuron
F C Liu, A M Graybiel

Abstract

The cAMP response element-binding protein (CREB) is a plasticity-associated transcription factor that can potentially integrate cAMP and calcium signals at the gene activation level. We tested for convergent Ser-133 phosphorylation of CREB via dopamine D1/D5 receptors and L-type calcium channels in organotypic cultures of neonatal striatum. We found such convergence only transiently. Sustained CREB phosphorylation by D1/D5 receptor and L-type channel agonists was targeted to opposite (striosome and matrix) cellular phenotypes. Subsequent expression of the CRE-containing gene, c-fos, matched the divergent patterns of sustained CREB phosphorylation, and both divergent patterns could be switched by inhibition of phosphatases, including calcineurin. Control of the duration of CREB phosphorylation may be a critical regulator of CRE-mediated gene expression by dopamine and calcium.

References

Jun 15, 1992·The Journal of Comparative Neurology·F C Liu, A M Graybiel
Apr 1, 1992·Current Opinion in Genetics & Development·P K Brindle, M R Montminy
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P K DashE R Kandel
May 1, 1990·Trends in Neurosciences·M R MontminyK K Yamamoto
Apr 1, 1991·Journal of Neuroscience Methods·L StoppiniD Muller
Jan 1, 1989·Experimental Brain Research·S Goto, A Hirano
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M C NowyckyR W Tsien
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Jun 1, 1995·Current Opinion in Neurobiology·H Schulman
May 12, 1995·Science·E Kandel, T Abel
Jun 1, 1994·Current Opinion in Neurobiology·M F Bear, R C Malenka
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·B H MinH H Loh

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Citations

Oct 20, 1998·Journal of Neurobiology·S Finkbeiner, M E Greenberg
May 3, 2003·Biochemical and Biophysical Research Communications·Melanie FöckingThorsten Trapp
Aug 2, 2002·European Journal of Pharmacology·Sangeeta Chawla
Apr 29, 1998·Brain Research. Molecular Brain Research·D J MessersmithM J Iadarola
Jul 26, 2003·Progress in Neurobiology·Thérèse M Jay
Jul 2, 2003·Brain Research Bulletin·Quanshun ZhangAmarendra M Kumar
Jun 12, 2001·Current Opinion in Neurobiology·B Mellström, J R Naranjo
Jun 1, 1997·Current Opinion in Neurobiology·H BitoR W Tsien
Mar 11, 1999·Current Opinion in Neurobiology·A Buonanno, R D Fields
Apr 2, 2005·Nature Reviews. Neuroscience·Zhengui Xia, Daniel R Storm
Apr 12, 2001·The European Journal of Neuroscience·J HallB J Everitt
Dec 14, 1999·The European Journal of Neuroscience·S BerrettaA M Graybiel
Oct 31, 2002·The European Journal of Neuroscience·Barbara MontiAntonio Contestabile
Nov 28, 2002·The European Journal of Neuroscience·Derek C MolliverEdwin W McCleskey
Mar 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Per SvenningssonPaul Greengard
Apr 4, 2003·Proceedings of the National Academy of Sciences of the United States of America·Shiv K SharmaThomas J Carew
Dec 14, 2001·Proceedings of the National Academy of Sciences of the United States of America·P G MermelsteinR W Tsien
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·T Tully
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·F C Liu, A M Graybiel
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·Z YanP Greengard
May 21, 2010·The Journal of Biological Chemistry·Michael W FriedrichOliver Griesbeck
Jan 22, 2005·Genes, Brain, and Behavior·K C BradleyP G Mermelstein
Apr 15, 2004·Molecular and Cellular Biology·Ghia EuskirchenMichael Snyder
Jun 29, 2000·Annual Review of Biochemistry·A J Shaywitz, M E Greenberg

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