Spatiotemporal electrocardiographic characterization of ventricular depolarization and repolarization abnormalities in long QT syndrome

Journal of Electrocardiology
Lioara Restier-MironPhilippe Chevalier

Abstract

If only a standard electrocardiogram (ECG) is available, at least 25% of patients with long QT syndrome (LQTS) may be missed. Our goal is to quantify abnormal electrical activity and to develop an ECG decision rule for the patients with LQTS. One hundred forty-one subjects were included in this study (71 patients with LQTS and 70 healthy subjects). A 12-lead digital ECG was recorded for each subject and analyzed using the CAVIAR (comparative analysis of ECG-VCG and their interpretation with auto-reference to the patient) method. A decision tree involving criteria based on 3 spatiotemporal ECG measurements-the QT interval and the maximum amplitude of the T wave, both corrected from heart rate, and the loss of planarity of the end of QRS-identified patients with LQTS from healthy subjects with a sensitivity of 89%, a specificity of 96%, and a total accuracy of 92%. This study suggests that 3-dimensional ECG analysis may improve the detection of patients with LQTS.

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Citations

Jul 19, 2012·Pediatric Cardiology·Ulla-Britt DiamantAnnika Rydberg
Mar 11, 2010·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Vy-Van LeVictor Froelicher
Dec 17, 2009·Journal of Electrocardiology·Ulla-Britt DiamantSteen M Jensen
Jan 29, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Antoine Delinière, Philippe Chevalier

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