Spatiotemporal evolution of focal epileptiform activity from surface and laminar field recordings in cat neocortex.

Journal of Neurophysiology
Hank BinkDiego Contreras

Abstract

New devices that use targeted electrical stimulation to treat refractory localization-related epilepsy have shown great promise, although it is not well known which targets most effectively prevent the initiation and spread of seizures. To better understand how the brain transitions from healthy to seizing on a local scale, we induced focal epileptiform activity in the visual cortex of five anesthetized cats with local application of the GABAA blocker picrotoxin while simultaneously recording local field potentials on a high-resolution electrocorticography array and laminar depth probes. Epileptiform activity appeared in the form of isolated events, revealing a consistent temporal pattern of ictogenesis across animals with interictal events consistently preceding the appearance of seizures. Based on the number of spikes per event, there was a natural separation between seizures and shorter interictal events. Two distinct spatial regions were seen: an epileptic focus that grew in size as activity progressed, and an inhibitory surround that exhibited a distinct relationship with the focus both on the surface and in the depth of the cortex. Epileptiform activity in the cortical laminae was seen concomitant with activity on the sur...Continue Reading

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Citations

Sep 17, 2019·Reviews in the Neurosciences·Roger D TraubStephen P Hall
Dec 13, 2019·Epilepsia·Brandy B MaVikram R Rao
Oct 11, 2019·Brain : a Journal of Neurology·Lohith G KiniBrian Litt

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