Abstract
Cochlin (encoded by COCH) constitutes 70% of non-collagenous protein in the inner ear, and the expression of cochlin is highly specific to the inner ear. Eleven missense mutation and one in-frame deletion have been reported in the COCH gene, causing hereditary progressive sensorineural hearing loss and vestibular dysfunction, DFNA9. These data imply that cochlin should bear an essential and crucial role in the inner ear function. However, the role of cochlin has not been fully clarified. We have investigated the spatiotemporal expression of cochlin in the inner ear of rats during postnatal development to better understand the functional role of cochlin. By immunohistochemistry, cochlin expression was faint in the cochlea and vestibule on the 6th day after birth (DAB6). At DAB70, strong expression of cochlin was detected in the spiral limbus and spiral ligament within the cochlea, and in the stromata of the maculae of otolithic organs and crista ampullaris within the vestibule. Immunoreactivity for cochlin increased during the postnatal development. Western blot analysis also showed an increase in the expression of cochlin isoforms. Furthermore, the dominant isoform of cochlin expressed changed from p63s to p40s between DAB24 an...Continue Reading
References
Feb 1, 1995·Anatomy and Embryology·T KikuchiJ C Adams
Jan 27, 1998·Genomics·N G RobertsonC C Morton
Nov 7, 1998·Nature Genetics·N G RobertsonJ G Seidman
Feb 5, 1999·Human Molecular Genetics·Y J de KokF P Cremers
Jul 13, 1999·Human Molecular Genetics·E FransenG Van Camp
Sep 28, 1999·The Laryngoscope·S J BomC W Cremers
Oct 28, 1999·Brain Research·A XiaT Takasaka
Aug 15, 2000·The Laryngoscope·U Khetarpal
Sep 6, 2000·European Journal of Biochemistry·M TrexlerL Patthy
Dec 22, 2000·Hearing Research·G ArmourG Dunaway
Mar 30, 2001·Biochimica Et Biophysica Acta·T IkezonoT Yagi
Apr 17, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T SuzukiT Takamatsu
Nov 16, 2001·Human Molecular Genetics·N G RobertsonC C Morton
Jul 5, 2003·Journal of Medical Genetics·N G RobertsonC C Morton
Sep 27, 2003·European Journal of Human Genetics : EJHG·Shin-ichi UsamiGuy Van Camp
Oct 3, 2003·The Tohoku Journal of Experimental Medicine·Zhen-Hua JinToshimitsu Kobayashi
Jan 22, 2004·Biochemical and Biophysical Research Communications·Tetsuo IkezonoToshiaki Yagi
May 12, 2005·Auris, Nasus, Larynx·Lishu LiToshiaki Yagi
Nov 2, 2005·American Journal of Medical Genetics. Part a·Valerie A StreetJames O Phillips
Dec 24, 2005·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Tetsuo IkezonoToshiaki Yagi
Feb 17, 2006·Human Molecular Genetics·Nahid G RobertsonCynthia C Morton
Jul 13, 2006·American Journal of Medical Genetics. Part a·Rob W J CollinHannie Kremer
Jun 15, 2007·The Annals of Otology, Rhinology, and Laryngology·Robert J PauwCor W R J Cremers
Oct 11, 2007·Journal of the Association for Research in Otolaryngology : JARO·P K KommareddiT E Carey
Feb 29, 2008·Neuroscience Letters·Kunihiro MizutaHiroyuki Mineta
Citations
Jan 26, 2010·Human Molecular Genetics·Mark R ChanceKumar Alagramam
Oct 2, 2012·Acta Oto-laryngologica·Kyoko ShiibaKimihiro Okubo
Jul 16, 2010·Acta Oto-laryngologica·Lishu LiToshiaki Yagi
Jul 1, 2020·Laryngoscope Investigative Otolaryngology·Chika SaegusaKaoru Ogawa
Sep 17, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery