Spatiotemporal Genetic Diversity of Lions Reveals the Influence of Habitat Fragmentation across Africa.

Molecular Biology and Evolution
Caitlin J CurryJames N Derr

Abstract

Direct comparisons between historical and contemporary populations allow for detecting changes in genetic diversity through time and assessment of the impact of habitat fragmentation. Here, we determined the genetic architecture of both historical and modern lions to document changes in genetic diversity over the last century. We surveyed microsatellite and mitochondrial genome variation from 143 high-quality museum specimens of known provenance, allowing us to directly compare this information with data from several recently published nuclear and mitochondrial studies. Our results provide evidence for male-mediated gene flow and recent isolation of local subpopulations, likely due to habitat fragmentation. Nuclear markers showed a significant decrease in genetic diversity from the historical (HE = 0.833) to the modern (HE = 0.796) populations, whereas mitochondrial genetic diversity was maintained (Hd = 0.98 for both). Although the historical population appears to have been panmictic based on nDNA data, hierarchical structure analysis identified four tiers of genetic structure in modern populations and was able to detect most sampling locations. Mitogenome analyses identified four clusters: Southern, Mixed, Eastern, and Wester...Continue Reading

References

May 20, 1999·Molecular Biology and Evolution·H J BandeltA Röhl
Apr 12, 2001·Molecular Ecology·J C Garza, E G Williamson
Dec 26, 2001·Proceedings. Biological Sciences·G Spong, S Creel
Mar 5, 2002·Genome Research·Carlos A DriscollStephen J O'Brien
Aug 12, 2006·Proceedings. Biological Sciences·Ross BarnettAlan Cooper
Jul 5, 2008·Science·George WittemyerJustin S Brashares
Oct 12, 2010·Science·Warren E JohnsonStephen J O'Brien
Jan 1, 2008·Molecular Ecology Resources·François Rousset
Jul 11, 2013·Ecology Letters·S CreelA Zimmermann
Aug 24, 2013·BMC Genomics·Snehal B BagathariaAkshay K Saxena
Aug 1, 2014·Ecology and Evolution·Talatu TendeBengt Hansson
Jan 2, 2015·Evolutionary Applications·Lewis G SpurginDavid S Richardson
Oct 28, 2015·Proceedings of the National Academy of Sciences of the United States of America·Hans BauerCraig Packer
Nov 26, 2015·Science Advances·Gerardo CeballosTodd M Palmer
Dec 25, 2015·PloS One·Susan M MillerPaul J Funston
Jul 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Kevin R CrooksLuigi Boitani
Jul 12, 2017·Proceedings of the National Academy of Sciences of the United States of America·Gerardo CeballosRodolfo Dirzo
Oct 14, 2017·Molecular Biology and Evolution·Julio RozasAlejandro Sánchez-Gracia
Mar 25, 2018·Forensic Science International. Genetics·Erin M GordenCharla Marshall
Aug 30, 2019·Evolutionary Applications·Deborah M LeighVicki L Friesen
May 6, 2020·Proceedings of the National Academy of Sciences of the United States of America·Marc de ManuelM Thomas P Gilbert

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