Spatiotemporal heterogeneity of CNS radial glial cells and their transition to restricted precursors

Developmental Biology
Hedong LiMartin Grumet

Abstract

Radial glia are among the first cells that develop in the embryonic central nervous system. They are progenitors of glia and neurons but their relationship with restricted precursors that are also derived from neuroepithelia is unclear. To clarify this issue, we analyzed expression of cell type specific markers (BLBP for radial glia, 5A5/E-NCAM for neuronal precursors and A2B5 for glial precursors) on cortical radial glia in vivo and their progeny in vitro. Clones of cortical cells initially expressing only BLBP gave rise to cells that were A2B5+ and eventually lost BLBP expression in vitro. BLBP is expressed in the rat neuroepithelium as early as E12.5 when there is little or no staining for A2B5 and 5A5. In E13.5-15.5 forebrain, A2B5 is spatially restricted co-localizing with a subset of the BLBP+ radial glia. Analysis of cells isolated acutely from embryonic cortices confirmed that BLBP expression could appear without, or together with, A2B5 or 5A5. The numbers of BLBP+/5A5+ cells decreased during neurogenesis while the numbers of BLBP+/A2B5+ cells remained high through the beginning of gliogenesis. The combined results demonstrate that spatially restricted subpopulations of radial glia along the dorsal-ventral axis acquire ...Continue Reading

References

Jul 1, 1991·The Journal of Cell Biology·A NishiyamaW B Stallcup
Sep 15, 1990·Experientia·P Rakic
Nov 1, 1984·Developmental Biology·M C RaffR H Miller
Feb 1, 1993·Current Opinion in Neurobiology·M E Hatten
Aug 1, 1997·Developmental Biology·M S Rao, M Mayer-Proschel
Nov 19, 1997·Trends in Neurosciences·A Martínez-Serrano, A Björklund
Nov 7, 1998·Journal of Neurobiology·D R FriedlanderM Grumet
Nov 21, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·G Chanas-SacréP Leprince
Jan 3, 2001·Developmental Biology·E HartfussM Götz
Apr 3, 2001·Nature Reviews. Neuroscience·A Alvarez-BuyllaA D Tramontin
Nov 2, 2001·Nature·S Temple
Dec 1, 2001·Journal of the American Society of Nephrology : JASN·Takahito ItoMasatsugu Hori
Jul 9, 2002·Current Opinion in Genetics & Development·David M Panchision, Ronald D G McKay
Oct 3, 2002·Results and Problems in Cell Differentiation·Mark F Mehler
Nov 19, 2002·Developmental Biology·Jingli CaiMahendra S Rao
Feb 21, 2003·Current Opinion in Neurobiology·Gord Fishell, Arnold R Kriegstein
Mar 12, 2003·Neuron·Paolo MalatestaMagdalena Götz

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Citations

Jun 18, 2005·Proceedings of the National Academy of Sciences of the United States of America·Bjorn SchefflerDennis A Steindler
Dec 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Florian T MerkleArturo Alvarez-Buylla
Nov 3, 2010·Cerebral Cortex·Amy A SarmaCharles A Greer
Mar 1, 2006·Archives of Histology and Cytology·Marjan MoreelsIvo Lambrichts
May 15, 2012·Molecular and Cellular Neurosciences·Antonio MassaroGianfranco Gennarini
Dec 22, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Chiu-Ming WenChung-Shung Wang
Jul 3, 2007·Gene Expression Patterns : GEP·Daniel P FitzgeraldHelen M Cooper
Sep 25, 2008·Developmental Neurobiology·Hedong LiMartin Grumet
Feb 27, 2009·Brain Pathology·Aurélie TchoghandjianDominique Figarella-Branger
Mar 1, 2012·Developmental Biology·Antonella BizzocaGianfranco Gennarini
Dec 14, 2005·International Review of Cytology·Esteban M RodríguezPedro Amat
Jan 29, 2010·Nature Reviews. Neuroscience·Luciano Conti, Elena Cattaneo
Apr 29, 2006·Neuroscience and Behavioral Physiology·L I KorochkinV E Okhotin
Mar 6, 2018·Analytical Chemistry·Linwen ZhangAkos Vertes
Feb 25, 2011·Colloids and Surfaces. B, Biointerfaces·Roberto Delgado-RiveraKathryn E Uhrich

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