PMID: 9655515Jul 9, 1998Paper

Spatiotemporal measurement of free radical elimination in the abdomen using an in vivo ESR-CT imaging system

Free Radical Biology & Medicine
H TogashiT Takahashi

Abstract

Electron spin resonance (ESR) imaging can visualize the distribution of free radicals in living systems according to their concentrations. However, the application of ESR imaging to living animals has not been well established. Using a rapid field scan L-band ESR imaging system, we have successfully obtained two-dimensional ESR projection (xz-plane projection) and three-dimensional ESR-CT (trans-axial section along the y-axis) images of the abdomen of living mice after an injection of 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (carbamoyl-PROXYL) into the tail vein. The in vivo two-dimensional ESR projection imaging clearly visualized the carbamoyl-PROXYL distribution and the rapid decay process in the abdomen. Because among the viscera, the liver is most abundantly associated with a blood volume, the outline of the image can be composed mainly of this organ. We therefore attempted to find whether there will be a difference in spatiotemporal dynamics of carbamoyl-PROXYL in the abdomens between the control and the mice with liver damage by two-dimensional ESR projection. In the control mice, carbamoyl-PROXYL was almost completely eliminated from the abdomen within 5 minutes after administration. On the other hand, in mice ...Continue Reading

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Citations

May 10, 2000·Free Radical Biology & Medicine·H TogashiH Kamada
Aug 11, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masaichi-Chang-Il LeeToshihiko Ozawa
Apr 18, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hitoshi TogashiKazuo Oikawa
May 4, 2016·Antioxidants & Redox Signaling·Giuseppe MaulucciMarco De Spirito
May 28, 2020·Free Radical Research·Tetsuro UchidaTakamasa Kayama
Nov 30, 2018·Journal of Clinical Biochemistry and Nutrition·Tetsuro UchidaTakamasa Kayama
Jun 22, 2021·Antioxidants & Redox Signaling·Ken-Ichiro MatsumotoIchio Aoki

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