Spatiotemporal memory is an intrinsic property of networks of dissociated cortical neurons

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Han JuAntonius M J VanDongen

Abstract

The ability to process complex spatiotemporal information is a fundamental process underlying the behavior of all higher organisms. However, how the brain processes information in the temporal domain remains incompletely understood. We have explored the spatiotemporal information-processing capability of networks formed from dissociated rat E18 cortical neurons growing in culture. By combining optogenetics with microelectrode array recording, we show that these randomly organized cortical microcircuits are able to process complex spatiotemporal information, allowing the identification of a large number of temporal sequences and classification of musical styles. These experiments uncovered spatiotemporal memory processes lasting several seconds. Neural network simulations indicated that both short-term synaptic plasticity and recurrent connections are required for the emergence of this capability. Interestingly, NMDA receptor function is not a requisite for these short-term spatiotemporal memory processes. Indeed, blocking the NMDA receptor with the antagonist APV significantly improved the temporal processing ability of the networks, by reducing spontaneously occurring network bursts. These highly synchronized events have disas...Continue Reading

Citations

Apr 12, 2016·Frontiers in Systems Neuroscience·Yuichiro YadaHirokazu Takahashi
Jun 11, 2016·PLoS Computational Biology·Pierre EnelPeter Ford Dominey
Mar 9, 2017·International Journal of Neural Systems·Xu ZhangSilvia Ferrari
Aug 8, 2015·Scientific Reports·Christian TetzlaffFlorentin Wörgötter
Feb 15, 2017·Reviews in the Neurosciences·Dennis J McFarland
Apr 23, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Luís F Seoane
Oct 3, 2020·Scientific Reports·Phuong Thi Mai NguyenToshiyuki Kondo
Dec 15, 2019·Scientific Reports·Terri P RobertsKevin Staras
Nov 14, 2020·Current Biology : CB·Michael R BaleMiguel Maravall
Jun 25, 2021·Frontiers in Computational Neuroscience·Yuan ZengZhiyuan Yan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Mark R DraniasAntonius M J VanDongen
Proceedings of the National Academy of Sciences of the United States of America
Elakkat D Gireesh, Dietmar Plenz
© 2022 Meta ULC. All rights reserved