Spatiotemporal pattern of macrophage recruitment after chronic nerve compression injury

Journal of Neurotrauma
Ranjan Gupta, Jennifer C Channual

Abstract

The contribution of macrophages to the pathogenesis of chronic nerve compression (CNC) injuries is presently unclear. We examined the time course and spatial localization of macrophage invasion from 24 hours to 28 days post-CNC injury with immunohistochemistry (IHC) and electron microscopy (EM). To clarify the differences in macrophage activity between different peripheral nerve injuries, we compared CNC injury to a nerve crush (CR) injury at similar time points. Entire counts of macrophages with ED1-immunoreactivity (IR) showed a slow, gradual increase in macrophage number from 24 hours to 28 days post-operatively in compressed sections. ED1-IR was greatest at the site of compression and in distal nerve segments with minimal immunostaining in proximal and normal sections. Quantitative analysis of ED1-IR after crush injury demonstrated a rapid time course of macrophage recruitment with ED1-IR peaking at 48 hours and declining to normal values as early as 21 days post-CR injury. Ultrastructural analysis with EM 14 days post-CNC injury revealed greater macrophage localization in the inner one-third region of normal nerves relative to the outer region. Differences in macrophage localization within inner and outer regions of compre...Continue Reading

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Citations

May 14, 2009·Neurosurgical Focus·Khoa Pham, Ranjan Gupta
Jul 31, 2013·Hand Clinics·Ron M G MenorcaJohn C Elfar
Jun 19, 2013·Journal of Neuropathology and Experimental Neurology·Annina B SchmidElspeth M McLachlan
Oct 14, 2008·The Journal of Pain : Official Journal of the American Pain Society·Sarah M RothmanBeth A Winkelstein
Aug 5, 2009·Microsurgery·Paul DinhRanjan Gupta
Jul 26, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Tahseen MozaffarRanjan Gupta
Apr 2, 2011·Neuropathology and Applied Neurobiology·D J ChewP J Shortland
Dec 17, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Laura Rummler FrieboesRanjan Gupta
Dec 3, 2014·Brain, Behavior, and Immunity·Juliette Van SteenwinckelStéphane Melik Parsadaniantz
Apr 5, 2011·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Petr Dubový
Jan 30, 2015·Journal of Neuroscience Methods·Stefano Geuna

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