Spatiotemporal Propagation of the Cortical Atrophy: Population and Individual Patterns

Frontiers in Neurology
Igor KovalStanley Durrleman

Abstract

Repeated failures in clinical trials for Alzheimer's disease (AD) have raised a strong interest for the prodromal phase of the disease. A better understanding of the brain alterations during this early phase is crucial to diagnose patients sooner, to estimate an accurate disease stage, and to give a reliable prognosis. According to recent evidence, structural alterations in the brain are likely to be sensitive markers of the disease progression. Neuronal loss translates in specific spatiotemporal patterns of cortical atrophy, starting in the enthorinal cortex and spreading over other cortical regions according to specific propagation pathways. We developed a digital model of the cortical atrophy in the left hemisphere from prodromal to diseased phases, which is built on the temporal alignment and combination of several short-term observation data to reconstruct the long-term history of the disease. The model not only provides a description of the spatiotemporal patterns of cortical atrophy at the group level but also shows the variability of these patterns at the individual level in terms of difference in propagation pathways, speed of propagation, and age at propagation onset. Longitudinal MRI datasets of patients with mild co...Continue Reading

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Citations

Mar 13, 2019·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Murat Bilgel, Bruno M Jedynak
Oct 20, 2020·Frontiers in Neurology·Alberto RedolfiEgidio D'Angelo
Jan 30, 2020·Computer Methods and Programs in Biomedicine·Gerard Martí-JuanGemma Piella
Mar 12, 2021·Frontiers in Big Data·Lars Lau Raket
Apr 15, 2021·Scientific Reports·Igor KovalStanley Durrleman
Jun 5, 2021·Brain Communications·Clément Abi NaderUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jun 7, 2021·NeuroImage·Vikram VenkatraghavanUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jun 8, 2021·Frontiers in Big Data·Damiano ArchettiUNKNOWN for Alzheimer’s Disease Neuroimaging Initiative and EuroPOND Consortium
Aug 31, 2021·Frontiers in Artificial Intelligence·Alexandra L YoungUNKNOWN Alzheimer’s Disease Neuroimaging Initiative

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